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The State of Genetically Modified Mouse Models in 2019 – Advances in Human Disease Research
Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas.
For your reference, we now briefly summarize several recent publications from researchers using custom genetically modified models for a broad range of human disease studies, including neurological disorders, inflammatory disorders, cardiovascular disease, oncology, immunology, and kidney disease.
|
Models |
Research Applications |
Title |
Journal |
|
Knockin mice (TurboKnockout® based) |
Neurology |
Oxytocin-dependent reopening of a social reward learning critical period with MDMA |
Nature, 2019 |
|
Knockin mice (ESC based) |
Cardiovasology |
Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition |
Scientific Reports, 2019. |
|
Knockout Mice
|
Inflammatory disorders |
VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. |
Science Advances, 2019 |
|
Neuropathology |
AQP4ex is crucial for the anchoring of AQP4 at the astrocyte end-feet and for neuromyelitis optica antibody binding |
Acta Neuropathologica Communications, 2019. |
|
|
Cardiovascular disease |
Inhibition of S-Adenosyl homocysteine Hydrolase Induces Endothelial Dysfunction via Epigenetic Regulation of p66shc-Mediated Oxidative Stress Pathway |
Circulation, 2019. |
|
|
Oncology |
Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer |
Free Radical Biology and Medicine, 2019. |
|
|
Conditional Knockout Mice
|
Osteoarthritis |
Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis. |
Nature Communications, 2019. |
|
Cardiovascular disease |
Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques. |
Journal of Experimental Medicine, 2019. |
|
|
Immunology |
Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses |
Immunity, 2019. |
|
|
Point Mutation Mice |
Pancreatic disease |
Heterozygous Spink1 c.194+2T>C mutant mice spontaneously develop chronic pancreatitis. |
Gut, 2019. |
|
Point Mutation Mice (Rosa26) |
Infertility |
A pannexin 1 channelopathy causes human oocyte death |
Science Translational Medicine, 2019. |
|
Rosa26 Conditional knockout Mice |
Kidney disease |
Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution |
Redox Biology, 2019. |
|
Transgenic Mice |
Cancer immunotherapy |
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy. |
Immunity, 2019. |
|
Immunology |
Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response |
PNAS (Proceedings of the National Academy of Sciences of the United States of America), 2019. |
|
|
Conditional Transgenic Mice |
Colorectal Cancer (CRC) |
CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p |
Journal of Experimental & Clinical Cancer Research, 2019. |
Visit our Citations page for a comprehensive, searchable listing of publications using custom animal models from Cyagen.
Did we miss you? Please contact us if you have published your studies using custom animal models provided by Cyagen that are not yet included in our citation resources.
If you need more information regarding our technologies and how Cyagen can help you further your research, please feel free to contact us with your gene target(s) and our custom model generation experts will be in touch with you.
サイヤジェン株式会社について
サイヤジェン株式会社は15年間の発展を経て、全世界の数万人の科学研究者にサービスを提供しており、製品と技術は直接にCNS (Cell、Nature、Science)の定期刊を含む5,200余りの学術論文に応用されています。弊社の「ノックアウトマウスライブラリ」は低価格だけでなく、遺伝子名称を入力すれば、ワンクリックで注文まで操作できます。 ノックアウトマウス、ノックインマウス、コンディショナルノックアウトマウス、トランスジェニックマウス、GFPマウス、免疫不全マウス、無菌マウスなどのカスタマイズサービスを提供する以外、専門的な手術疾患モデルチームがあり、多種の複雑な小動物手術疾患モデルも提供できます。
