Bmpr1b-flox Mouse
一般名
Bmpr1b-flox
製品ID
S-CKO-01441
背景情報
C57BL/6JCya
系統ID
CKOCMP-12167-Bmpr1b-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Bmpr1b-flox Mouse（カタログ番号S-CKO-01441）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Bmpr1b-flox
系統ID
CKOCMP-12167-Bmpr1b-B6J-VA
遺伝子名
製品ID
S-CKO-01441
遺伝子別名
Alk6, SKR6, ALK-6, Acvrlk6, BMPR-1B, BMPR-IB, CFK-43a
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 3
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000029948
NCBIトランスクリプトID
NM_007560
ターゲット領域
Exon 3~4
有効領域の大きさ
~1.8 kb
遺伝子研究の概要
Bmpr1b, short for Bone morphogenetic protein receptor type 1B, is a multifunctional signaling molecule in the canonical bone morphogenetic protein (BMP)/Sma-and mad-related protein (Smad) signaling pathway. It is well-known as the first major gene associated with sheep prolificacy [5]. Bmpr1b also plays a role in ovarian function and folliculogenesis in mammals, and its disruption is related to primary ovarian insufficiency (POI) [2,3].
In sheep, the FecB mutation in Bmpr1b, located near the binding site of the small molecule repressor protein FKBP1A, may increase the ovulation rate by affecting the intensity of the interactions between Bmpr1b and FKBP1A, thus changing the activity in the BMP/SMAD pathway [1]. In human studies, missense mutations in Bmpr1b lead to an impairment of downstream BMP signaling, unveiling a link between Bmpr1b variants and the origin of POI [3]. Also, Bmpr1b mutations are likely a cause of Pierre Robin sequence [4]. Additionally, Bmpr1b polymorphisms are associated with breast cancer susceptibility in Chinese Han women [6], and the lncRNA SNHG6/miR-125b-5p/Bmpr1b axis may be a new therapeutic target for triple-negative breast cancer [7]. In sheep granulosa cells, miR-1306 can inhibit Bmpr1b and promote cell apoptosis, potentially improving sheep fecundity [8]. In endometriosis patients, the lncRNA BMPR1B-AS1, regulated by IGF2BP2, affects decidualization through the SMAD1/5/9 pathway [9]. Genetically defined Bmpr1b-labeled DRG neurons are involved in mediating behavioral responses to high colon distension and over-reactivity in a model of inflammatory bowel disease [10].
In conclusion, Bmpr1b is crucial in multiple biological processes such as ovarian function, folliculogenesis, and sheep prolificacy. Its mutations and polymorphisms are associated with various diseases including POI, Pierre Robin sequence, and breast cancer. The study of Bmpr1b through different models helps in understanding the underlying molecular mechanisms of these biological processes and diseases, providing potential targets for diagnosis, treatment, and genetic improvement.
References：
1. Gong, Yi-Ming, Wang, Xiang-Yu, He, Xiao-Yun, Chu, Ming-Xing, Di, Ran. . Progress on the effect of FecB mutation on BMPR1B activity and BMP/SMAD pathway in sheep. In Yi chuan = Hereditas, 45, 295-305. doi:10.16288/j.yczz.22-366. https://pubmed.ncbi.nlm.nih.gov/37077164/
2. França, Monica Malheiros, Mendonca, Berenice Bilharinho. 2021. Genetics of ovarian insufficiency and defects of folliculogenesis. In Best practice & research. Clinical endocrinology & metabolism, 36, 101594. doi:10.1016/j.beem.2021.101594. https://pubmed.ncbi.nlm.nih.gov/34794894/
3. Renault, Lucie, Patiño, Liliana C, Magnin, Françoise, Binart, Nadine, Beau, Isabelle. . BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency. In The Journal of clinical endocrinology and metabolism, 105, . doi:10.1210/clinem/dgz226. https://pubmed.ncbi.nlm.nih.gov/31769494/
4. Yang, Yongjia, Yuan, Jianying, Yao, Xu, Tu, Ming, Zhu, Yimin. . BMPR1B mutation causes Pierre Robin sequence. In Oncotarget, 8, 25864-25871. doi:10.18632/oncotarget.16531. https://pubmed.ncbi.nlm.nih.gov/28418932/
5. Abdurahman, Anwar, Du, Xing, Yao, Yilong, Aniwashi, Jueken, Li, Qifa. 2019. Smad4 Feedback Enhances BMPR1B Transcription in Ovine Granulosa Cells. In International journal of molecular sciences, 20, . doi:10.3390/ijms20112732. https://pubmed.ncbi.nlm.nih.gov/31167348/
6. Zheng, Yi, Jiang, Xun, Wang, Meng, Kang, Huafeng, Chen, Lei. 2022. BMPR1B Polymorphisms (rs1434536 and rs1970801) are Associated With Breast Cancer Susceptibility in Northwest Chinese Han Females: A Case-Control Study. In Clinical breast cancer, 22, e641-e646. doi:10.1016/j.clbc.2022.02.011. https://pubmed.ncbi.nlm.nih.gov/35501253/
7. Lv, Yufei, Lv, Xiaohong, Yang, Huike, Zhang, Jianguo, Zhang, Yafang. 2021. LncRNA SNHG6/miR-125b-5p/BMPR1B Axis: A New Therapeutic Target for Triple-Negative Breast Cancer. In Frontiers in oncology, 11, 678474. doi:10.3389/fonc.2021.678474. https://pubmed.ncbi.nlm.nih.gov/34026654/
8. Abdurahman, Anwar, Aierken, Wusimanjiang, Zhang, Fei, Aniwashi, Jueken, Sulayman, Ablat. 2022. miR-1306 induces cell apoptosis by targeting BMPR1B gene in the ovine granulosa cells. In Frontiers in genetics, 13, 989912. doi:10.3389/fgene.2022.989912. https://pubmed.ncbi.nlm.nih.gov/36212145/
9. Que, Xiaohong, Ren, Lulu, Yang, Lin, Wu, Rongfeng, Chen, Qionghua. . Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 38, e23622. doi:10.1096/fj.202302195R. https://pubmed.ncbi.nlm.nih.gov/38703029/
10. Wolfson, Rachel L, Abdelaziz, Amira, Rankin, Genelle, Sharma, Nikhil, Ginty, David D. . DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon. In Cell, 186, 3368-3385.e18. doi:10.1016/j.cell.2023.07.007. https://pubmed.ncbi.nlm.nih.gov/37541195/
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凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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