Drd3-flox Mouse
一般名
Drd3-flox
製品ID
S-CKO-02092
背景情報
C57BL/6JCya
系統ID
CKOCMP-13490-Drd3-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Drd3-flox Mouse（カタログ番号S-CKO-02092）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Drd3-flox
系統ID
CKOCMP-13490-Drd3-B6J-VA
遺伝子名
製品ID
S-CKO-02092
遺伝子別名
D3R
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 16
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000023390
NCBIトランスクリプトID
NM_007877
ターゲット領域
Exon 2
有効領域の大きさ
~0.9 kb
遺伝子研究の概要
Drd3, the dopamine receptor D3 gene, encodes a G protein-coupled receptor that is a key component of the dopamine signaling pathway. Dopamine signaling is involved in numerous physiological and neurological processes, such as motor control, reward-based learning, and emotional regulation. The gene is highly expressed in the basal ganglia, most notably the caudate nucleus [1,4].
In autism spectrum disorder (ASD), the SNP rs167771 of Drd3 has been associated with the disorder in samples from multiple regions. The polymorphisms of rs167771 are significantly linked to a specific repetitive and stereotyped behavior called sameness. Additionally, these polymorphisms are related to risperidone-induced extra-pyramidal side effects in ASD patients. Moreover, an association between alleles of the rs167771 SNP and the volume of striatal structures was found, with greater caudate nucleus volume correlating with stereotyped behavior [1,4].
In schizophrenia, the Ser9Gly polymorphism of Drd3 is associated with treatment response to antipsychotic drugs in Caucasians but not in Asians. The Ser allele and Ser/Ser genotype contribute to poor treatment response in Caucasians [2].
Early life stress (ELS)-induced downregulation of Drd3 signaling in the lateral septum causes social abnormalities in adulthood, and optogenetic or pharmacological activation of Drd3-expressing neurons in the lateral septum rescues these impairments [3].
In Parkinson's disease, the Drd3 Ser9Gly polymorphism might be associated with the severity of depression characterized by anhedonia [5].
In ADHD, the T allele of the Ser-9-Gly polymorphism in Drd3 shows a nominal association with increased risk for ADHD, response to placebo and methylphenidate, and modulation of other behavioral and cognitive dimensions. Also, COMT and Drd3 genetic variants may interact to play a role in ADHD symptomatology and response to treatment [6,7].
In conclusion, Drd3 plays a crucial role in various neurological and psychiatric conditions, including autism, schizophrenia, Parkinson's disease, and ADHD. Through genetic studies and animal models, we have gained insights into how Drd3 polymorphisms and signaling alterations contribute to the pathophysiology of these diseases, which may potentially lead to the development of more targeted therapeutic strategies.
References：
1. Staal, Wouter G. 2014. Autism, DRD3 and repetitive and stereotyped behavior, an overview of the current knowledge. In European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 25, 1421-6. doi:10.1016/j.euroneuro.2014.08.011. https://pubmed.ncbi.nlm.nih.gov/25224105/
2. Liu, Chuanyong, Xu, Xiaohong, Liu, Xiaoyan, Li, Yaoyao, Yan, Pan. 2022. DRD3 Ser9Gly polymorphism and treatment response to antipsychotics in schizophrenia: A meta-analysis. In Neuroscience letters, 786, 136788. doi:10.1016/j.neulet.2022.136788. https://pubmed.ncbi.nlm.nih.gov/35835396/
3. Shin, Sora, Pribiag, Horia, Lilascharoen, Varoth, Wang, Xiao-Yun, Lim, Byung Kook. 2017. Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction. In Neuron, 97, 195-208.e6. doi:10.1016/j.neuron.2017.11.040. https://pubmed.ncbi.nlm.nih.gov/29276054/
4. Staal, Wouter G, Langen, Marieke, van Dijk, Sarai, Mensen, Vincent T, Durston, Sarah. 2015. DRD3 gene and striatum in autism spectrum disorder. In The British journal of psychiatry : the journal of mental science, 206, 431-2. doi:10.1192/bjp.bp.114.148973. https://pubmed.ncbi.nlm.nih.gov/25792691/
5. Zhi, Yan, Yuan, Yongsheng, Si, Qianqian, Zhang, Hui, Zhang, Kezhong. 2019. The Association between DRD3 Ser9Gly Polymorphism and Depression Severity in Parkinson's Disease. In Parkinson's disease, 2019, 1642087. doi:10.1155/2019/1642087. https://pubmed.ncbi.nlm.nih.gov/31143436/
6. Fageera, Weam, Sengupta, Sarojini M, Labbe, Aurelie, Grizenko, Natalie, Joober, Ridha. 2018. DRD3 Gene and ADHD: A Pharmaco-Behavioural Genetic Study. In Neuromolecular medicine, 20, 515-524. doi:10.1007/s12017-018-8504-z. https://pubmed.ncbi.nlm.nih.gov/30051166/
7. Fageera, Weam, Grizenko, Natalie, Sengupta, Sarojini M, Schmitz, Norbert, Joober, Ridha. 2020. COMT by DRD3 Epistatic Interaction in Modulating Behaviors in Children with ADHD: A Pharmaco-Dynamic Behavioral Approach. In Journal of attention disorders, 25, 1720-1730. doi:10.1177/1087054720934191. https://pubmed.ncbi.nlm.nih.gov/32564645/
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