Sdc1-flox Mouse
一般名
Sdc1-flox
製品ID
S-CKO-05480
背景情報
C57BL/6NCya
系統ID
CKOCMP-20969-Sdc1-B6N-VA
状況
このマウス系統を論文で使用する場合は、「Sdc1-flox Mouse（カタログ番号S-CKO-05480）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Sdc1-flox
系統ID
CKOCMP-20969-Sdc1-B6N-VA
遺伝子名
製品ID
S-CKO-05480
遺伝子別名
Sstn, Synd, CD138, Synd1, syn-1
遺伝子別名
C57BL/6NCya
NCBI ID
修正
Conditional knockout
染色体
Chr 12
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000020911
NCBIトランスクリプトID
NM_011519
ターゲット領域
Exon 2
有効領域の大きさ
~0.6 kb
遺伝子研究の概要
SDC1, also known as Syndecan-1 or CD138, is a cell-surface adhesion molecule crucial for maintaining cell morphology and interactions with the surrounding microenvironment. It binds to various ligands and influences cell growth and reproduction via the activation of pathways like Wnt, FLIP long, VEGFR, MAPK/ERK, and MAPK/JNK [2]. SDC1 is involved in multiple biological processes related to cancer and other diseases.
In cancer research, SDC1 shows diverse roles. In pancreatic cancer, single-cell RNA-seq revealed a CCL5-SDC1/4 receptor-ligand interaction between T cells and tumor cells, and CCL5 promoted tumor cell migration via SDC1 in vitro [1]. SDC1 has different effects in various cancers: reduced expression is associated with advanced stages in gastric and colorectal cancer, while overexpression promotes growth and proliferation in pancreatic and breast cancer [2]. In glioblastoma, SDC1 was overexpressed in radio-resistant cells and tissues, and the SDC1-TGM2-FLOT1-BHMT complex enhanced radio-resistance by influencing autophagosome-lysosome fusion [3]. In hepatic carcinoma, SDC1 promoted cisplatin resistance via the PI3K-AKT pathway [4]. In breast cancer, SDC1 was highly expressed, and silencing it blocked cell proliferation, migration, and invasion [5]. In colorectal cancer, high SDC1 expression in stromal cells was associated with good prognosis, while loss of SDC1 expression in cancer tissues indicated poor prognosis [6,7]. In gallbladder cancer, SDC1 knockdown promoted cell proliferation, invasion, and migration possibly by regulating the ERK/Snail pathway and inducing epithelial-mesenchymal transition [8].
In conclusion, SDC1 plays a complex and context-dependent role in various diseases, especially in cancer. Its functions range from influencing cell-to-cell interactions, cancer cell growth, metastasis, and drug resistance. Research on SDC1 using gene-knockout or other loss-of-function models has provided valuable insights into its role in disease development, which may help identify new therapeutic targets for treating related diseases.
References：
1. Chen, Kai, Wang, Yazhou, Hou, Yuting, Tian, Xiaodong, Yang, Yinmo. 2022. Single cell RNA-seq reveals the CCL5/SDC1 receptor-ligand interaction between T cells and tumor cells in pancreatic cancer. In Cancer letters, 545, 215834. doi:10.1016/j.canlet.2022.215834. https://pubmed.ncbi.nlm.nih.gov/35917973/
2. Liao, Shiyao, Liu, Chang, Zhu, Guiying, Yang, Ying, Wang, Changmiao. 2019. Relationship between SDC1 and cadherin signalling activation in cancer. In Pathology, research and practice, 216, 152756. doi:10.1016/j.prp.2019.152756. https://pubmed.ncbi.nlm.nih.gov/31810587/
3. Zeng, Liang, Zheng, Wang, Liu, Xinglong, Zhang, Jianghong, Shao, Chunlin. 2023. SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomes. In Theranostics, 13, 3725-3743. doi:10.7150/thno.81999. https://pubmed.ncbi.nlm.nih.gov/37441590/
4. Yu, Liquan, Xu, Hong, Zhang, Song, Chen, Jiangming, Yu, Zhongshan. 2020. SDC1 promotes cisplatin resistance in hepatic carcinoma cells via PI3K-AKT pathway. In Human cell, 33, 721-729. doi:10.1007/s13577-020-00362-6. https://pubmed.ncbi.nlm.nih.gov/32314115/
5. Song, Guoqing, Ma, Yao, Ma, Yinghan, Cao, Yanan, Zhao, Yi. . miR-335-5p Targets SDC1 to Regulate the Progression of Breast Cancer. In Critical reviews in eukaryotic gene expression, 32, 21-31. doi:10.1615/CritRevEukaryotGeneExpr.2022041813. https://pubmed.ncbi.nlm.nih.gov/35997115/
6. Li, Zhejie, He, Shujin, Liu, Jianli, Li, Lei, Wang, Wei. 2022. High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer. In Anti-cancer drugs, 34, 479-482. doi:10.1097/CAD.0000000000001441. https://pubmed.ncbi.nlm.nih.gov/36730554/
7. Li, Kaizhi, Li, Lei, Wu, Xiaoxiao, Li, Yan, Wang, Wei. 2019. Loss of SDC1 Expression Is Associated with Poor Prognosis of Colorectal Cancer Patients in Northern China. In Disease markers, 2019, 3768708. doi:10.1155/2019/3768708. https://pubmed.ncbi.nlm.nih.gov/31182980/
8. Liu, Zixiang, Jin, Hao, Yang, Song, Wen, Bo, Zhou, Shaobo. . SDC1 knockdown induces epithelial-mesenchymal transition and invasion of gallbladder cancer cells via the ERK/Snail pathway. In The Journal of international medical research, 48, 300060520947883. doi:10.1177/0300060520947883. https://pubmed.ncbi.nlm.nih.gov/32812461/
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