Mrps10-flox Mouse
一般名
Mrps10-flox
製品ID
S-CKO-12775
背景情報
C57BL/6JCya
系統ID
CKOCMP-64657-Mrps10-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Mrps10-flox Mouse（カタログ番号S-CKO-12775）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Mrps10-flox
系統ID
CKOCMP-64657-Mrps10-B6J-VA
遺伝子名
製品ID
S-CKO-12775
遺伝子別名
Rpms10, 1110038B19Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 17
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000119945
NCBIトランスクリプトID
NM_001146212
ターゲット領域
Exon 4
有効領域の大きさ
~0.8 kb
遺伝子研究の概要
Mrps10, a mitochondrial ribosomal protein gene, is an essential component for the structural and functional integrity of the mitoribosome complex. Mitoribosomes play a crucial role in mitochondrial translation, which is vital for the synthesis of proteins involved in oxidative phosphorylation and energy production. As part of the mitoribosome, Mrps10 is thus important for normal mitochondrial function and overall cellular metabolism [1].
In a study on pigs, MRPS10 was identified as a hub gene in a protein-protein interaction network related to abdominal subcutaneous fat deposition. It was also considered a potential obese-specific biomarker, suggesting its role in fat metabolism-related biological processes [3]. In thyroid cancer, lower expression of MRPS10 was observed, and it was part of a senescence-related signature that could predict prognosis and immunotherapy response, indicating its possible involvement in cancer-related biological behaviors [2]. In rheumatoid arthritis, MRPS10 was one of the validated biomarkers related to energy and reactive oxygen species (ROS) metabolism, linked to oxidative phosphorylation, and may be involved in the pathogenesis of the disease [4]. In a study on intensive care unit-acquired weakness, miR-542-3p suppressed the expression of MRPS10, leading to mitochondrial ribosomal stress, suggesting its importance in muscle-related mitochondrial function [5]. In a cancer cell line panel study, overexpression of MRPS10 was found in breast cancer, and its protein-protein interactions indicated a putative role in fatty acid oxidation regulated by the brain-derived neurotrophic factor signaling pathway [6].
In conclusion, Mrps10 is crucial for mitoribosome function and cellular metabolism. Its role has been implicated in various disease conditions such as obesity-related fat deposition, thyroid cancer, rheumatoid arthritis, muscle-related mitochondrial function in intensive care unit-acquired weakness, and breast cancer. These findings from different research models help to understand the diverse biological functions of Mrps10 and its potential significance in disease mechanisms.
References：
1. Cheong, Agnes, Lingutla, Ranjana, Mager, Jesse. 2020. Expression analysis of mammalian mitochondrial ribosomal protein genes. In Gene expression patterns : GEP, 38, 119147. doi:10.1016/j.gep.2020.119147. https://pubmed.ncbi.nlm.nih.gov/32987154/
2. Hong, Kai, Cen, Kenan, Chen, Qiaoqiao, Mai, Yifeng, Guo, Yangyang. 2023. Identification and validation of a novel senescence-related biomarker for thyroid cancer to predict the prognosis and immunotherapy. In Frontiers in immunology, 14, 1128390. doi:10.3389/fimmu.2023.1128390. https://pubmed.ncbi.nlm.nih.gov/36761753/
3. Yang, Yongli, Wang, Xiaoyi, Li, Mingli, Chen, Qiang, Lu, Shaoxiong. 2024. Identification of potential obese-specific biomarkers and pathways associated with abdominal subcutaneous fat deposition in pig using a comprehensive bioinformatics strategy. In PeerJ, 12, e17486. doi:10.7717/peerj.17486. https://pubmed.ncbi.nlm.nih.gov/38832038/
4. Gao, Conghui, Zhang, Chengqiang, Wen, Lixing, Duan, Jiaoniu, Guo, Yingying. 2025. Regulation of reactive oxygen species and the role of mitochondrial apoptotic-related genes in rheumatoid arthritis. In Scientific reports, 15, 2165. doi:10.1038/s41598-025-85460-x. https://pubmed.ncbi.nlm.nih.gov/39820483/
5. Garros, Roser Farre, Paul, Richard, Connolly, Martin, Polkey, Michael I, Kemp, Paul R. . MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit-acquired Weakness. In American journal of respiratory and critical care medicine, 196, 1422-1433. doi:10.1164/rccm.201701-0101OC. https://pubmed.ncbi.nlm.nih.gov/28809518/
6. Revathi Paramasivam, Oviya, Gopisetty, Gopal, Subramani, Jayavelu, Thangarajan, Rajkumar. . Expression and affinity purification of recombinant mammalian mitochondrial ribosomal small subunit (MRPS) proteins and protein-protein interaction analysis indicate putative role in tumourigenic cellular processes. In Journal of biochemistry, 169, 675-692. doi:10.1093/jb/mvab004. https://pubmed.ncbi.nlm.nih.gov/34492114/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
環境基準:
SPF対応地域:
グローバル由来:
Cyagenお問い合わせ
カスタムの動物モデルに関するご相談は、下記のフォームにご記入いただき、ご連絡いただくか見積もりをご依頼ください。
Cyagenはお客様のプライバシーを大変重視しています。当社の最新の製品や情報をお届けしたいと思っています。お客様の設定をご確認ください。
これらの配信はいつでも解除できます。配信停止方法およびデータ保護の詳細は プライバシーポリシー をご確認ください。
以下のボタンをクリックすることで、このフォームにご入力いただいた個人情報をCyagenが保存・処理し、ご要望のコンテンツを提供することに同意されたことになります。