Coro1a-KO Mouse

Coro1a, short for Coronin 1A, is an actin-binding protein that plays crucial roles in multiple biological processes. It is involved in cytoskeleton remodeling, which is essential for various cellular functions such as cell movement, endocytosis, and cell-cell communication. Additionally, it participates in pathways related to steroidogenesis, neuronal morphogenesis, and autophagy [1,2,4].

In studies related to cadmium (Cd) exposure, Cd-treated male offspring showed up-regulation of Coro1a in testis, leading to F-actin disassembly, reduced LDL uptake, and decreased progesterone production. Silencing Coro1a rescued these effects, highlighting its role in Cd-induced steroid hormone deficiency [1]. In neuronal morphogenesis, Coro1A localizes to growth cones and filopodial structures and is required for netrin-dependent axon turning, branching, and corpus callosum development, collaborating with TRIM67 [2]. In triple-negative breast cancer (TNBC), CORO1A is crucial for the disease progression, and its degradation by a molecular glue degrader via TRIM4 exerted antitumor effects [3]. In non-alcoholic steatohepatitis (NASH), CREBH inhibits Coro1a expression, and overexpression of Coro1a in liver cells inhibits autophagic flux and elevates inflammatory cytokine levels [4].

In conclusion, Coro1a is essential for cytoskeleton-related functions, steroidogenesis, neuronal development, and autophagy-related processes. Its study through gene-based models has provided insights into diseases like Cd-induced steroid hormone deficiency, TNBC, and NASH, highlighting its potential as a therapeutic target in these disease areas.

References:

1. Wang, Youjin, Li, Teng, Li, Haoji, Huang, Yadong, Zhang, Qihao. 2022. CORO1A regulates lipoprotein uptake in Leydig cells exposed to cadmium. In Ecotoxicology and environmental safety, 232, 113255. doi:10.1016/j.ecoenv.2022.113255. https://pubmed.ncbi.nlm.nih.gov/35121256/

2. Ho, Chris T, Evans, Elliot B, Lukasik, Kimberly, Bear, James E, Gupton, Stephanie L. 2025. Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis. In bioRxiv : the preprint server for biology, , . doi:10.1101/2025.03.20.644333. https://pubmed.ncbi.nlm.nih.gov/40166342/

3. Gu, Wen-Jie, Liu, Xiao-Xia, Shen, Yi-Wen, Jin, Jin-Mei, Luan, Xin. 2024. TRIM4 enhances small-molecule-induced neddylated-degradation of CORO1A for triple negative breast cancer therapy. In Theranostics, 14, 7023-7041. doi:10.7150/thno.97662. https://pubmed.ncbi.nlm.nih.gov/39629122/

4. Deng, Xiaoling, Liu, Beibei, Jiang, Qianqian, Li, Jiahuan, Xu, Keshu. 2023. CREBH promotes autophagy to ameliorate NASH by regulating Coro1a. In Biochimica et biophysica acta. Molecular basis of disease, 1870, 166914. doi:10.1016/j.bbadis.2023.166914. https://pubmed.ncbi.nlm.nih.gov/37837948/