Comt-KO Mouse
一般名
Comt-KO
製品ID
S-KO-01594
背景情報
C57BL/6NCya
系統ID
KOCMP-12846-Comt-B6N-VA
状況
このマウス系統を論文で使用する場合は、「Comt-KO Mouse（カタログ番号S-KO-01594）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Comt-KO
系統ID
KOCMP-12846-Comt-B6N-VA
遺伝子名
製品ID
S-KO-01594
遺伝子別名
Comt1, D16Wsu103e, D330014B15Rik
遺伝子別名
C57BL/6NCya
NCBI ID
修正
Conventional knockout
染色体
Chr 16
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000115609
NCBIトランスクリプトID
NM_007744
ターゲット領域
Exon 3~4
有効領域の大きさ
~0.6 kb
遺伝子研究の概要
COMT, short for Catechol-O-Methyltransferase, is an enzyme responsible for the O-methylation of biologically active catechol-based molecules. It is involved in catecholamine metabolism, a pathway crucial for the proper functioning of the nervous system, and has been associated with several neurological disorders [4]. Its genetic variants have been the subject of extensive research, with genetic models helping to understand its role in health and disease.
COMT inhibitors have been established in the treatment of Parkinson's disease for over 20 years, considered the medication of choice for motor fluctuations [1]. The Val158Met polymorphism of COMT may influence the risk for psychopathy-related behaviors in children and adolescents, with different genotypes showing varying likelihoods of displaying such traits depending on age [2]. Genetic variants of COMT, along with DCX and FMR1, have been linked to neurodevelopmental disorders related to intellectual disability and social behavior, potentially converging at Wnt signaling, neuron migration, and axon and dendrite morphogenesis [3]. In Fragile X Syndrome, COMT expression is significantly reduced, affecting dopamine signaling [5]. Also, the COMT rs4680 polymorphism has been studied in relation to antidepressive treatment response, Parkinson's disease risk, and levodopa-induced dyskinesia in Parkinson's disease patients, with some associations found but inconsistent results across studies [6,7,8].
In conclusion, COMT is essential for catecholamine metabolism and is involved in multiple neurological and neuropsychiatric conditions. Studies using genetic models, though not specifically KO/CKO mouse models in the provided references, have shed light on its role in diseases like Parkinson's disease, psychopathy-related behaviors, and Fragile X Syndrome. Understanding COMT's function through these models may help in developing better treatment strategies for associated disorders.
References:
1. Jost, Wolfgang H, Buhmann, Carsten, Classen, Joseph, Woitalla, Dirk, Reichmann, Heinz. 2022. [Relevance of COMT inhibitors in the treatment of motor fluctuations]. In Der Nervenarzt, 93, 1035-1045. doi:10.1007/s00115-021-01237-3. https://pubmed.ncbi.nlm.nih.gov/35044481/
2. Kant, Tuana, Koyama, Emiko, Zai, Clement C, Beitchman, Joseph H, Kennedy, James L. 2022. COMT Val/Met and Psychopathic Traits in Children and Adolescents: A Systematic Review and New Evidence of a Developmental Trajectory toward Psychopathy. In International journal of molecular sciences, 23, . doi:10.3390/ijms23031782. https://pubmed.ncbi.nlm.nih.gov/35163702/
3. Delprato, Anna, Xiao, Emily, Manoj, Devika. 2022. Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment. In Behavioral and brain functions : BBF, 18, 7. doi:10.1186/s12993-022-00191-7. https://pubmed.ncbi.nlm.nih.gov/35590332/
4. Cruz-Vicente, Pedro, Gonçalves, Ana M, Barroca-Ferreira, Jorge, Gallardo, Eugénia, Passarinha, Luis A. 2022. Unveiling the biopathway for the design of novel COMT inhibitors. In Drug discovery today, 27, 103328. doi:10.1016/j.drudis.2022.07.013. https://pubmed.ncbi.nlm.nih.gov/35907613/
5. Utami, Kagistia Hana, Yusof, Nur Amirah Binte Muhammed, Garcia-Miralles, Marta, Langley, Sarah R, Pouladi, Mahmoud A. 2023. Dysregulated COMT Expression in Fragile X Syndrome. In Neuromolecular medicine, 25, 644-649. doi:10.1007/s12017-023-08754-1. https://pubmed.ncbi.nlm.nih.gov/37684514/
6. Tang, Zhen, Zhang, Shumin, Guo, Dongmei, Wang, Hanyan. 2020. Association between COMT gene Val108/158Met and antidepressive treatment response: A meta-analysis. In Gene, 734, 144333. doi:10.1016/j.gene.2020.144333. https://pubmed.ncbi.nlm.nih.gov/31972309/
7. Jiménez-Jiménez, Félix J, Alonso-Navarro, Hortensia, García-Martín, Elena, Agúndez, José A G. . COMT gene and risk for Parkinson's disease: a systematic review and meta-analysis. In Pharmacogenetics and genomics, 24, 331-9. doi:10.1097/FPC.0000000000000056. https://pubmed.ncbi.nlm.nih.gov/24819480/
8. Yin, Yanying, Liu, Yang, Xu, Meisong, Zhang, XiaoMin, Li, Chen. 2021. Association of COMT rs4680 and MAO-B rs1799836 polymorphisms with levodopa-induced dyskinesia in Parkinson's disease-a meta-analysis. In Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 42, 4085-4094. doi:10.1007/s10072-021-05509-3. https://pubmed.ncbi.nlm.nih.gov/34346015/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
環境基準:
SPF対応地域:
グローバル由来:
Cyagenお問い合わせ
カスタムの動物モデルに関するご相談は、下記のフォームにご記入いただき、ご連絡いただくか見積もりをご依頼ください。
Cyagenはお客様のプライバシーを大変重視しています。当社の最新の製品や情報をお届けしたいと思っています。お客様の設定をご確認ください。
これらの配信はいつでも解除できます。配信停止方法およびデータ保護の詳細は プライバシーポリシー をご確認ください。
以下のボタンをクリックすることで、このフォームにご入力いただいた個人情報をCyagenが保存・処理し、ご要望のコンテンツを提供することに同意されたことになります。