Sdc1-KO Mouse
一般名
Sdc1-KO
製品ID
S-KO-04693
背景情報
C57BL/6NCya
系統ID
KOCMP-20969-Sdc1-B6N-VA
状況
このマウス系統を論文で使用する場合は、「Sdc1-KO Mouse（カタログ番号S-KO-04693）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Sdc1-KO
系統ID
KOCMP-20969-Sdc1-B6N-VA
遺伝子名
製品ID
S-KO-04693
遺伝子別名
Sstn, Synd, CD138, Synd1, syn-1
遺伝子別名
C57BL/6NCya
NCBI ID
修正
Conventional knockout
染色体
Chr 12
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000020911
NCBIトランスクリプトID
NM_011519
ターゲット領域
Exon 2~4
有効領域の大きさ
~2.0 kb
遺伝子研究の概要
SDC1, also known as Syndecan-1 or CD138, is a key cell surface adhesion molecule crucial for maintaining cell morphology and interactions with the surrounding microenvironment. It binds to various ligands and influences cell growth and reproduction via the activation of pathways such as Wnt, FLIP long, VEGFR, MAPK/ERK, and MAPK/JNK [2]. SDC1 is involved in multiple biological processes, and its abnormal expression is associated with various diseases, especially cancers [2-8, 10].
In cancer research, SDC1 shows different effects in various types of cancers. In pancreatic cancer, scRNA-seq analysis found CCL5-SDC1/4 receptor-ligand interactions between T cells and tumor cells, and CCL5 promoted tumor cell migration via interacting with SDC1 in vitro [1]. In breast cancer, SDC1 is highly expressed, and silencing it blocks cell proliferation, migration, and invasion [5]. In contrast, in colorectal cancer, reduced SDC1 expression is related to poor prognosis, while high SDC1 expression in stromal cells is associated with a good prognosis [6,8]. In gallbladder cancer, SDC1 knockdown promotes cell proliferation, invasion, and migration possibly by regulating the ERK/Snail signaling pathway and inducing EMT [7]. In hepatic carcinoma, SDC1 promotes cisplatin resistance via the PI3K-AKT pathway [4]. In glioblastoma, SDC1 overexpression contributes to radioresistance by influencing the fusion of autophagosomes with lysosomes through the SDC1-TGM2-FLOT1-BHMT complex [3].
In conclusion, SDC1 plays diverse and complex roles in different biological processes and diseases, especially in cancer. Its abnormal expression can either promote or inhibit cancer progression depending on the cancer type. Studies on SDC1 help to understand the molecular mechanisms of diseases and may provide new targets for immunotherapy and cancer treatment.
References:
1. Chen, Kai, Wang, Yazhou, Hou, Yuting, Tian, Xiaodong, Yang, Yinmo. 2022. Single cell RNA-seq reveals the CCL5/SDC1 receptor-ligand interaction between T cells and tumor cells in pancreatic cancer. In Cancer letters, 545, 215834. doi:10.1016/j.canlet.2022.215834. https://pubmed.ncbi.nlm.nih.gov/35917973/
2. Liao, Shiyao, Liu, Chang, Zhu, Guiying, Yang, Ying, Wang, Changmiao. 2019. Relationship between SDC1 and cadherin signalling activation in cancer. In Pathology, research and practice, 216, 152756. doi:10.1016/j.prp.2019.152756. https://pubmed.ncbi.nlm.nih.gov/31810587/
3. Zeng, Liang, Zheng, Wang, Liu, Xinglong, Zhang, Jianghong, Shao, Chunlin. 2023. SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by influencing the fusion of autophagosomes with lysosomes. In Theranostics, 13, 3725-3743. doi:10.7150/thno.81999. https://pubmed.ncbi.nlm.nih.gov/37441590/
4. Yu, Liquan, Xu, Hong, Zhang, Song, Chen, Jiangming, Yu, Zhongshan. 2020. SDC1 promotes cisplatin resistance in hepatic carcinoma cells via PI3K-AKT pathway. In Human cell, 33, 721-729. doi:10.1007/s13577-020-00362-6. https://pubmed.ncbi.nlm.nih.gov/32314115/
5. Song, Guoqing, Ma, Yao, Ma, Yinghan, Cao, Yanan, Zhao, Yi. . miR-335-5p Targets SDC1 to Regulate the Progression of Breast Cancer. In Critical reviews in eukaryotic gene expression, 32, 21-31. doi:10.1615/CritRevEukaryotGeneExpr.2022041813. https://pubmed.ncbi.nlm.nih.gov/35997115/
6. Li, Zhejie, He, Shujin, Liu, Jianli, Li, Lei, Wang, Wei. 2022. High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer. In Anti-cancer drugs, 34, 479-482. doi:10.1097/CAD.0000000000001441. https://pubmed.ncbi.nlm.nih.gov/36730554/
7. Liu, Zixiang, Jin, Hao, Yang, Song, Wen, Bo, Zhou, Shaobo. . SDC1 knockdown induces epithelial-mesenchymal transition and invasion of gallbladder cancer cells via the ERK/Snail pathway. In The Journal of international medical research, 48, 300060520947883. doi:10.1177/0300060520947883. https://pubmed.ncbi.nlm.nih.gov/32812461/
8. Li, Kaizhi, Li, Lei, Wu, Xiaoxiao, Li, Yan, Wang, Wei. 2019. Loss of SDC1 Expression Is Associated with Poor Prognosis of Colorectal Cancer Patients in Northern China. In Disease markers, 2019, 3768708. doi:10.1155/2019/3768708. https://pubmed.ncbi.nlm.nih.gov/31182980/
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