Dscc1-KO Mouse
一般名
Dscc1-KO
製品ID
S-KO-20080
背景情報
C57BL/6JCya
系統ID
KOCMP-72107-Dscc1-B6J-VB
状況
このマウス系統を論文で使用する場合は、「Dscc1-KO Mouse（カタログ番号S-KO-20080）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Dscc1-KO
系統ID
KOCMP-72107-Dscc1-B6J-VB
遺伝子名
製品ID
S-KO-20080
遺伝子別名
Dcc1, 2010006I05Rik, 2600005O03Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 15
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000110231
NCBIトランスクリプトID
NM_001355594
ターゲット領域
Exon 2
有効領域の大きさ
~1.5 kb
遺伝子研究の概要
Dscc1, or DNA replication and sister chromatid cohesion 1, is involved in DNA replication, repair, and sister chromatid cohesion (SCC) as a component of the alternative replication factor C (RFC) complex [6]. It also plays a role in the DNA double-strand break (DSB) repair pathway choice, promoting homologous recombination (HR) repair during the S/G2 phase [5].
In mouse mutant lines, null mice for Dscc1 showed a significant increase in micronucleus (MN) formation, along with phenotypes characteristic of patients with cohesinopathy disorders [1]. In human cancers, high DSCC1 expression is associated with poor prognosis in lung adenocarcinoma (LUAD), gastric cancer, and breast cancer [2,4,10]. In LUAD, it promotes cell proliferation, stemness, EMT, and metastatic potential, and interacts with HSP90AB1 to regulate ER stress [3]. In gastric cancer, transcription factor E2F4 upregulates DSCC1 expression, promoting cell proliferation, migration, and invasion [7]. Also, multi-omics analyses suggest its potential as a pan-cancer biomarker and therapeutic target [8,9].
In conclusion, Dscc1 is crucial for maintaining genomic stability through its functions in DNA-related processes. Mouse models with Dscc1 knockout have revealed its role in conditions related to genomic instability, such as micronucleus formation and phenotypes similar to cohesinopathy disorders. In the context of cancer, high DSCC1 expression is often associated with poor prognosis and cancer progression, indicating its potential as a biomarker and therapeutic target in multiple cancer types.
References：
1. Adams, D J, Barlas, B, McIntyre, R E, Jackson, S P, Balmus, G. 2024. Genetic determinants of micronucleus formation in vivo. In Nature, 627, 130-136. doi:10.1038/s41586-023-07009-0. https://pubmed.ncbi.nlm.nih.gov/38355793/
2. Chang, Sisi, Zhu, Yahui, Xi, Yutan, Ma, Chunzheng, Li, Honglin. 2021. High DSCC1 Level Predicts Poor Prognosis of Lung Adenocarcinoma. In International journal of general medicine, 14, 6961-6974. doi:10.2147/IJGM.S329482. https://pubmed.ncbi.nlm.nih.gov/34707388/
3. Lin, Xu, Liu, Ye-Han, Zhang, Huan-Qi, Li, Yang-Ling, Hu, Jian. 2023. DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress. In Cancer cell international, 23, 208. doi:10.1186/s12935-023-03047-w. https://pubmed.ncbi.nlm.nih.gov/37742009/
4. Hou, Shiyang, Zhang, Jie, Chi, Xiaoqian, Kang, Chunbo, Shan, Haifeng. . Roles of DSCC1 and GINS1 in gastric cancer. In Medicine, 102, e35681. doi:10.1097/MD.0000000000035681. https://pubmed.ncbi.nlm.nih.gov/37904396/
5. Tian, Jiaxin, Li, Jiaheng, Liu, Fengqi, Zhang, Haoxing, Chen, Guo. 2025. DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair. In Cell reports, 44, 115452. doi:10.1016/j.celrep.2025.115452. https://pubmed.ncbi.nlm.nih.gov/40117291/
6. van Schie, Janne Jm, de Lint, Klaas, Pai, Govind M, Wolthuis, Rob Mf, de Lange, Job. 2022. MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC. In Life science alliance, 6, . doi:10.26508/lsa.202201596. https://pubmed.ncbi.nlm.nih.gov/36622344/
7. Baral, Shantanu, Yu, Yantao, Sun, Qiannan, Wang, Sen, Wang, Daorong. 2024. Transcription Factor E2F4 Promote Proliferation, Migration, and Invasion of Gastric Cancer Cells by transcriptionally activating DSCC1. In International journal of biological sciences, 20, 4978-4998. doi:10.7150/ijbs.99590. https://pubmed.ncbi.nlm.nih.gov/39309429/
8. Wang, Jingru, Gilani, Sana Fatima, Noor, Nazia, Hassan, Syed Sairum, Hameed, Yasir. 2024. Decoding the DSCC1 gene as a pan-cancer biomarker in human cancers via comprehensive multi-omics analyses. In American journal of translational research, 16, 738-754. doi:10.62347/YORR3755. https://pubmed.ncbi.nlm.nih.gov/38586115/
9. Cheng, Wei, Lin, Peng. 2025. DSCC1 Identified as Promising Tumor Biomarker and Potential Therapeutic Target Through Comprehensive Multi-omics Analysis and Experimental Validation. In Molecular biotechnology, , . doi:10.1007/s12033-025-01404-w. https://pubmed.ncbi.nlm.nih.gov/39992486/
10. Aljohani, Abrar I. 2024. Prognostic Significance of DSCC1, a Biomarker Associated with Aggressive Features of Breast Cancer. In Medicina (Kaunas, Lithuania), 60, . doi:10.3390/medicina60121929. https://pubmed.ncbi.nlm.nih.gov/39768811/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
環境基準:
SPF対応地域:
グローバル由来:
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