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Prdm1-iCre (Blimp1-iCre)
製品ID :
I001198
系統:
C57BL/6JCya
状況:
説明:
The PR/SET domain 1 (PRDM1 or BLIMP1) gene encodes a transcriptional repressor. It inhibits the expression of interferon-β (IFN-β) genes and plays a crucial role during mouse germ cell formation. Additionally, by suppressing the gene expression program in mature B cells, PRDM1 drives B cells to differentiate into antibody-secreting plasma cells. PRDM1 is widely expressed during development, including in migrating germ cells. Research has shown that mice with defective Prdm1 genes exhibit abnormal primordial germ cell (PGC)-like cells during early embryonic development, which fail to proliferate or migrate normally. Prdm1-Cre mice are useful for tissue-specific studies targeting PGCs [1].
The Prdm1-iCre (Blimp1-iCre) mouse is generated by integrating the P2A-iCre expression cassette into the stop codon of the mouse Prdm1 gene. Under the control of mouse Prdm1 gene regulatory elements, this strain expresses iCre recombinase (codon-optimized Cre recombinase). Using peptide 2A (P2A) avoids decreasing protein activity and downstream gene expression levels during multigene expression. When Prdm1-iCre (Blimp1-iCre) mice are crossed with mice containing loxP sites, Cre-mediated sequence recombination occurs in the offspring’s primordial germ cells.
The PR/SET domain 1 (PRDM1 or BLIMP1) gene encodes a transcriptional repressor. It inhibits the expression of interferon-β (IFN-β) genes and plays a crucial role during mouse germ cell formation. Additionally, by suppressing the gene expression program in mature B cells, PRDM1 drives B cells to differentiate into antibody-secreting plasma cells. PRDM1 is widely expressed during development, including in migrating germ cells. Research has shown that mice with defective Prdm1 genes exhibit abnormal primordial germ cell (PGC)-like cells during early embryonic development, which fail to proliferate or migrate normally. Prdm1-Cre mice are useful for tissue-specific studies targeting PGCs [1].
The Prdm1-iCre (Blimp1-iCre) mouse is generated by integrating the P2A-iCre expression cassette into the stop codon of the mouse Prdm1 gene. Under the control of mouse Prdm1 gene regulatory elements, this strain expresses iCre recombinase (codon-optimized Cre recombinase). Using peptide 2A (P2A) avoids decreasing protein activity and downstream gene expression levels during multigene expression. When Prdm1-iCre (Blimp1-iCre) mice are crossed with mice containing loxP sites, Cre-mediated sequence recombination occurs in the offspring’s primordial germ cells.
Cfap418-KO
製品ID :
S-KO-12142
系統:
C57BL/6JCya
状況:
説明:
Cfap418 is located on chromosome 4 of mice. Nuclease Technology will be used to design sgRNA; Cfap418 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Cfap418 is located on chromosome 4 of mice. Nuclease Technology will be used to design sgRNA; Cfap418 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Prdm1-KO
製品ID :
S-KO-01229
系統:
C57BL/6JCya
状況:
説明:
Prdm1 is located on chromosome 10 of mice. Nuclease Technology was used to design sgRNA; Prdm1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Prdm1 is located on chromosome 10 of mice. Nuclease Technology was used to design sgRNA; Prdm1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Prdm1-flox
製品ID :
S-CKO-01425
系統:
C57BL/6JCya
状況:
説明:
Prdm1 is located on chromosome 10 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Prdm1 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Prdm1 is located on chromosome 10 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Prdm1 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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