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Cftr-KO
製品ID :
C001890
系統:
C57BL/6JCya
状況:
説明:
Cystic Fibrosis (CF) is an autosomal recessive disorder causing severe damage to the lungs, digestive system, and other organs. It thickens mucus, sweat, and digestive fluids, blocking ducts and channels. The disease manifests as a persistent cough, hyperinflation of lung lobes, chronic nasal congestion, headaches, sleep disorders, digestive and reproductive system disorders, and nutritional and growth development disorders. CF is caused by mutations in the CF-transmembrane conductance regulator (CFTR) gene, which encodes a cAMP-dependent chloride ion channel protein. Abnormal CFTR function can cause transmembrane transport disorders of chloride ions and bicarbonate, leading to mucus obstruction in exocrine glands, and affecting respiration, digestion, endocrine, and reproduction [1-2].
Cftr-KO mice are a gene-knockout (KO) model. Using gene-editing technology, exons 5-6 of the Cftr gene in mice have been knocked out. This model can be used for research on the pathogenic mechanism of cystic fibrosis and the development of related treatment methods. Homozygous Cftr-KO mice start to die at 2 weeks of age, and prophylactic PEG treatment can improve their survival rate [3]. This strain requires feeding with intestinal cleansers to maintain survival after 3 weeks of age.
Cystic Fibrosis (CF) is an autosomal recessive disorder causing severe damage to the lungs, digestive system, and other organs. It thickens mucus, sweat, and digestive fluids, blocking ducts and channels. The disease manifests as a persistent cough, hyperinflation of lung lobes, chronic nasal congestion, headaches, sleep disorders, digestive and reproductive system disorders, and nutritional and growth development disorders. CF is caused by mutations in the CF-transmembrane conductance regulator (CFTR) gene, which encodes a cAMP-dependent chloride ion channel protein. Abnormal CFTR function can cause transmembrane transport disorders of chloride ions and bicarbonate, leading to mucus obstruction in exocrine glands, and affecting respiration, digestion, endocrine, and reproduction [1-2].
Cftr-KO mice are a gene-knockout (KO) model. Using gene-editing technology, exons 5-6 of the Cftr gene in mice have been knocked out. This model can be used for research on the pathogenic mechanism of cystic fibrosis and the development of related treatment methods. Homozygous Cftr-KO mice start to die at 2 weeks of age, and prophylactic PEG treatment can improve their survival rate [3]. This strain requires feeding with intestinal cleansers to maintain survival after 3 weeks of age.
Cftr-flox
製品ID :
S-CKO-01710
系統:
C57BL/6JCya
状況:
説明:
Cftr is located on chromosome 6 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Cftr conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Cftr is located on chromosome 6 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Cftr conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Vmn2r103-flox
製品ID :
S-CKO-12638
系統:
C57BL/6JCya
状況:
説明:
Vmn2r103 is located on chromosome 17 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Vmn2r103 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Vmn2r103 is located on chromosome 17 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Vmn2r103 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Ccdc34-KO
製品ID :
S-KO-12638
系統:
C57BL/6JCya
状況:
説明:
Ccdc34 is located on chromosome 2 of mice. Nuclease Technology will be used to design sgRNA; Ccdc34 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Ccdc34 is located on chromosome 2 of mice. Nuclease Technology will be used to design sgRNA; Ccdc34 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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