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5 件の結果が “13711” で取得されました
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Elf5-Cre
製品ID :
C001389
系統:
C57BL/6JCya
状況:
説明:
The E26 transforming sequence (ETS) transcription factor family plays a key role in the embryogenesis or determination of cell subtypes in the endocellular clusters during mammary gland development. The E74-like ETS transcription factor 5 (ELF5) gene encodes a member of the epithelial-specific ETS family of transcription factors. In addition to playing a role in the late stages of terminal differentiation of keratinocytes, ELF5 also regulates many epithelial-specific genes in tissues containing glandular epithelium, such as the salivary glands and prostate [1]. ELF5 is an important regulator in the transformation and differentiation of mammary cell subtypes and is also considered a tumor suppressor transcription factor in breast cancer [2-3].
The Elf5-Cre mice were constructed using gene editing technology to insert the P2A-Cre expression element into the endogenous Elf5 gene of mice. The expression pattern of Cre recombinase is similar to that of the endogenous gene. When this strain is crossed with mice containing loxP sites, sequence recombination between loxP sites mediated by Cre recombinase can occur in tissues such as the mammary gland and uterus of offspring mice. The heterozygotes are viable and fertile.
The E26 transforming sequence (ETS) transcription factor family plays a key role in the embryogenesis or determination of cell subtypes in the endocellular clusters during mammary gland development. The E74-like ETS transcription factor 5 (ELF5) gene encodes a member of the epithelial-specific ETS family of transcription factors. In addition to playing a role in the late stages of terminal differentiation of keratinocytes, ELF5 also regulates many epithelial-specific genes in tissues containing glandular epithelium, such as the salivary glands and prostate [1]. ELF5 is an important regulator in the transformation and differentiation of mammary cell subtypes and is also considered a tumor suppressor transcription factor in breast cancer [2-3].
The Elf5-Cre mice were constructed using gene editing technology to insert the P2A-Cre expression element into the endogenous Elf5 gene of mice. The expression pattern of Cre recombinase is similar to that of the endogenous gene. When this strain is crossed with mice containing loxP sites, sequence recombination between loxP sites mediated by Cre recombinase can occur in tissues such as the mammary gland and uterus of offspring mice. The heterozygotes are viable and fertile.
Mtfr1-flox
製品ID :
S-CKO-13711
系統:
C57BL/6JCya
状況:
説明:
Mtfr1 is located on chromosome 3 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Mtfr1 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Mtfr1 is located on chromosome 3 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Mtfr1 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Cfap52-KO
製品ID :
S-KO-13711
系統:
C57BL/6JCya
状況:
説明:
Cfap52 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Cfap52 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Cfap52 is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Cfap52 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Elf5-flox
製品ID :
S-CKO-21840
系統:
C57BL/6JCya
状況:
説明:
Elf5 is located on chromosome 2 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Elf5 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Elf5 is located on chromosome 2 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Elf5 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Elf5-KO
製品ID :
S-KO-23498
系統:
C57BL/6JCya
状況:
説明:
Elf5 is located on chromosome 2 of mice. Nuclease Technology will be used to design sgRNA; Elf5 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Elf5 is located on chromosome 2 of mice. Nuclease Technology will be used to design sgRNA; Elf5 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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