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Gaa KO
製品ID :
C001702
系統:
C57BL/6JCya
状況:
説明:
The GAA gene encodes lysosomal acid alpha-glucosidase, a critical enzyme responsible for the hydrolysis of glycogen within lysosomes. Expressed across various tissues, including muscle and liver, GAA resides on mouse chromosome 11 and human chromosome 17 and follows an autosomal recessive inheritance pattern [1]. Pathogenic mutations in GAA lead to Glycogen Storage Disease Type II, commonly known as Pompe disease, a condition characterized by the intralysosomal accumulation of glycogen [2]. This accumulation primarily affects cardiac and skeletal muscle, resulting in progressive muscle weakness. In severe infantile-onset cases, Pompe disease manifests with marked cardiomyopathy and respiratory insufficiency [2-3]. Animal models deficient in Gaa have proven invaluable for elucidating disease mechanisms and evaluating therapeutic interventions.
The Gaa KO mouse is a gene knockout model created using gene-editing techniques to knock out the coding sequence of the Gaa gene (the homolog of the human GAA gene) in mice. This model is used to research the pathogenic mechanisms of Glycogen Storage Disease Type II (Pompe disease) and develop related therapeutic strategies.
The GAA gene encodes lysosomal acid alpha-glucosidase, a critical enzyme responsible for the hydrolysis of glycogen within lysosomes. Expressed across various tissues, including muscle and liver, GAA resides on mouse chromosome 11 and human chromosome 17 and follows an autosomal recessive inheritance pattern [1]. Pathogenic mutations in GAA lead to Glycogen Storage Disease Type II, commonly known as Pompe disease, a condition characterized by the intralysosomal accumulation of glycogen [2]. This accumulation primarily affects cardiac and skeletal muscle, resulting in progressive muscle weakness. In severe infantile-onset cases, Pompe disease manifests with marked cardiomyopathy and respiratory insufficiency [2-3]. Animal models deficient in Gaa have proven invaluable for elucidating disease mechanisms and evaluating therapeutic interventions.
The Gaa KO mouse is a gene knockout model created using gene-editing techniques to knock out the coding sequence of the Gaa gene (the homolog of the human GAA gene) in mice. This model is used to research the pathogenic mechanisms of Glycogen Storage Disease Type II (Pompe disease) and develop related therapeutic strategies.
Gaa-KO
製品ID :
S-KO-18579
系統:
C57BL/6JCya
状況:
説明:
Gaa is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Gaa knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Gaa is located on chromosome 11 of mice. Nuclease Technology was used to design sgRNA; Gaa knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Gaa-flox
製品ID :
S-CKO-18952
系統:
C57BL/6JCya
状況:
説明:
Gaa is located on chromosome 11 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Gaa conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Gaa is located on chromosome 11 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Gaa conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Meak7-KO
製品ID :
S-KO-14387
系統:
C57BL/6JCya
状況:
説明:
Meak7 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Meak7 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Meak7 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Meak7 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Lyzl4-flox
製品ID :
S-CKO-14387
系統:
C57BL/6JCya
状況:
説明:
Lyzl4 is located on chromosome 9 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Lyzl4 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Lyzl4 is located on chromosome 9 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Lyzl4 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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