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5 件の結果が “16161” で取得されました
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Il12rb1 KO
製品ID :
C001214
系統:
C57BL/6NCya
状況:
説明:
The Il12rb1 gene encodes a type I transmembrane protein that belongs to the hematopoietin receptor superfamily. This protein binds to interleukin-12 (IL-12) with low affinity and participates in IL-12 signal transduction. When combined with IL12RB2, it forms a functional high-affinity receptor for IL-12. The co-expression of this protein and IL12RB2 has been shown to create high-affinity IL-12 binding sites and reconstruct IL-12-dependent signal transduction. Mutations in the Il12rb1 gene impair the development of T lymphocytes that produce interleukin-17 and increase susceptibility to mycobacterial and Salmonella infections. Il12rb1 knockout (KO) homozygous mice exhibit reduced serum levels of interferon-gamma (IFN-γ) in response to recombinant IL-12 or lipopolysaccharide (LPS) treatment. Additionally, splenocytes from these mice activated by concanavalin A (ConA) in response to IL-12 cannot proliferate or secrete IFN-γ[1]. These homozygous mice are viable and fertile.
The Il12rb1 gene encodes a type I transmembrane protein that belongs to the hematopoietin receptor superfamily. This protein binds to interleukin-12 (IL-12) with low affinity and participates in IL-12 signal transduction. When combined with IL12RB2, it forms a functional high-affinity receptor for IL-12. The co-expression of this protein and IL12RB2 has been shown to create high-affinity IL-12 binding sites and reconstruct IL-12-dependent signal transduction. Mutations in the Il12rb1 gene impair the development of T lymphocytes that produce interleukin-17 and increase susceptibility to mycobacterial and Salmonella infections. Il12rb1 knockout (KO) homozygous mice exhibit reduced serum levels of interferon-gamma (IFN-γ) in response to recombinant IL-12 or lipopolysaccharide (LPS) treatment. Additionally, splenocytes from these mice activated by concanavalin A (ConA) in response to IL-12 cannot proliferate or secrete IFN-γ[1]. These homozygous mice are viable and fertile.
Atg16l2-KO
製品ID :
S-KO-16161
系統:
C57BL/6JCya
状況:
説明:
Atg16l2 is located on chromosome 7 of mice. Nuclease Technology was used to design sgRNA; Atg16l2 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Atg16l2 is located on chromosome 7 of mice. Nuclease Technology was used to design sgRNA; Atg16l2 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Zc2hc1b-flox
製品ID :
S-CKO-16161
系統:
C57BL/6JCya
状況:
説明:
Zc2hc1b is located on chromosome 10 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Zc2hc1b conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Zc2hc1b is located on chromosome 10 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Zc2hc1b conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Il12rb1-KO
製品ID :
S-KO-22816
系統:
C57BL/6JCya
状況:
説明:
Il12rb1 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Il12rb1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il12rb1 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Il12rb1 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il12rb1-flox
製品ID :
S-CKO-03080
系統:
C57BL/6JCya
状況:
説明:
Il12rb1 is located on chromosome 8 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Il12rb1 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Il12rb1 is located on chromosome 8 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Il12rb1 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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