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H11-Myh6-iCre
製品ID :
I001038
系統:
C57BL/6JCya
状況:
説明:
Cardiac myosin is a hexamer composed of two heavy chain sub-units, two light chain sub-units, and two regulatory sub-units, and the protein encoded by myosin heavy chain 6 (MYH6, also known as alpha-MHC) is cardiac myosin alpha heavy chain sub-unit. This gene is located approximately 4 kb downstream of the gene encoding the beta heavy chain sub-unit of cardiac myosin, and mutations in this gene are associated with familial hypertrophic cardiomyopathy and atrial septal defect.
This strain carries a mouse Myh6 gene promoter-driven Improved Cre (iCre) recombinase gene expression element insertion in the H11 safe harbor. When H11-Myh6-iCre mice are crossed with mice with floxed target genes, Cre recombinase-mediated sequence recombination between the loxP sites is induced in the cardiomyocytes of offspring. The homozygous and heterozygous H11-Myh6-iCre mice are viable and fertile.
Cardiac myosin is a hexamer composed of two heavy chain sub-units, two light chain sub-units, and two regulatory sub-units, and the protein encoded by myosin heavy chain 6 (MYH6, also known as alpha-MHC) is cardiac myosin alpha heavy chain sub-unit. This gene is located approximately 4 kb downstream of the gene encoding the beta heavy chain sub-unit of cardiac myosin, and mutations in this gene are associated with familial hypertrophic cardiomyopathy and atrial septal defect.
This strain carries a mouse Myh6 gene promoter-driven Improved Cre (iCre) recombinase gene expression element insertion in the H11 safe harbor. When H11-Myh6-iCre mice are crossed with mice with floxed target genes, Cre recombinase-mediated sequence recombination between the loxP sites is induced in the cardiomyocytes of offspring. The homozygous and heterozygous H11-Myh6-iCre mice are viable and fertile.
Myh6-MerCreMer
製品ID :
C001831
系統:
C57BL/6JCya
状況:
説明:
The Myh6 gene encodes the α-myosin heavy chain (α-MHC), a critical contractile protein predominantly expressed in cardiomyocytes, with species-specific variation in its spatial distribution: in humans, it is highly abundant in the atria and minimally expressed in adult ventricles (where β-MHC/MYH7 dominates), whereas in rodents, it serves as the primary ventricular motor protein [1]. This gene produces a "fast" myosin ATPase that drives rapid actin-myosin cross-bridge cycling, directly influencing cardiac contraction velocity, force generation, and power output. Myh6 expression dynamically regulates cardiac development and function; its downregulation (e.g., in heart failure or pressure overload) shifts the α-MHC/β-MHC ratio toward slower contraction, reducing cardiac efficiency and contributing to systolic dysfunction. Additionally, Myh6 hosts the intronic miRNA miR-208a, which fine-tunes stress-responsive gene networks, including thyroid hormone signaling and fetal gene reprogramming during hypertrophy [2]. Beyond contractile roles, Myh6 serves as a key marker for cardiomyocyte identity validation in cellular reprogramming and stem cell differentiation studies.
Myh6-MerCreMer mice were generated by inserting a Tamoxifen-inducible Cre recombinase protein MerCreMer gene expression element controlled by the mouse Myh6 promoter into the mouse H11 safe harbor site. Before induction, MerCreMer is only present in the cytoplasm and can only enter the nucleus to exert its recombination effect after Tamoxifen treatment. When bred with mice containing a loxP site-flanked sequence, Cre recombinase-mediated deletion of the flanked sequence will occur in the cardiomyocytes of the offspring after Tamoxifen induction. Compared with the Myh6-CreEsr1 mouse strain (Catalog No.: C001443), this strain shows improved survival outcomes in mice after tamoxifen induction.
The Myh6 gene encodes the α-myosin heavy chain (α-MHC), a critical contractile protein predominantly expressed in cardiomyocytes, with species-specific variation in its spatial distribution: in humans, it is highly abundant in the atria and minimally expressed in adult ventricles (where β-MHC/MYH7 dominates), whereas in rodents, it serves as the primary ventricular motor protein [1]. This gene produces a "fast" myosin ATPase that drives rapid actin-myosin cross-bridge cycling, directly influencing cardiac contraction velocity, force generation, and power output. Myh6 expression dynamically regulates cardiac development and function; its downregulation (e.g., in heart failure or pressure overload) shifts the α-MHC/β-MHC ratio toward slower contraction, reducing cardiac efficiency and contributing to systolic dysfunction. Additionally, Myh6 hosts the intronic miRNA miR-208a, which fine-tunes stress-responsive gene networks, including thyroid hormone signaling and fetal gene reprogramming during hypertrophy [2]. Beyond contractile roles, Myh6 serves as a key marker for cardiomyocyte identity validation in cellular reprogramming and stem cell differentiation studies.
Myh6-MerCreMer mice were generated by inserting a Tamoxifen-inducible Cre recombinase protein MerCreMer gene expression element controlled by the mouse Myh6 promoter into the mouse H11 safe harbor site. Before induction, MerCreMer is only present in the cytoplasm and can only enter the nucleus to exert its recombination effect after Tamoxifen treatment. When bred with mice containing a loxP site-flanked sequence, Cre recombinase-mediated deletion of the flanked sequence will occur in the cardiomyocytes of the offspring after Tamoxifen induction. Compared with the Myh6-CreEsr1 mouse strain (Catalog No.: C001443), this strain shows improved survival outcomes in mice after tamoxifen induction.
Ppp1cb-flox
製品ID :
S-CKO-17888
系統:
C57BL/6JCya
状況:
説明:
Ppp1cb is located on chromosome 5 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Ppp1cb conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Ppp1cb is located on chromosome 5 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Ppp1cb conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Pmpcb-KO
製品ID :
S-KO-17888
系統:
C57BL/6JCya
状況:
説明:
Pmpcb is located on chromosome 5 of mice. Nuclease Technology will be used to design sgRNA; Pmpcb knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Pmpcb is located on chromosome 5 of mice. Nuclease Technology will be used to design sgRNA; Pmpcb knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Myh6-KO
製品ID :
S-KO-17416
系統:
C57BL/6JCya
状況:
説明:
Myh6 is located on chromosome 14 of mice. Nuclease Technology was used to design sgRNA; Myh6 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Myh6 is located on chromosome 14 of mice. Nuclease Technology was used to design sgRNA; Myh6 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Myh6-flox
製品ID :
S-CKO-18346
系統:
C57BL/6JCya
状況:
説明:
Myh6 is located on chromosome 14 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Myh6 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Myh6 is located on chromosome 14 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Myh6 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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