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Pde6b KO
製品ID :
C001384
系統:
C57BL/6JCya
状況:
説明:
Phosphodiesterase 6B (PDE6B) is a protein-coding gene that encodes a protein that is part of the cGMP phosphodiesterase (cGMP-PDE) protein complex, a peripheral membrane isomerase consisting of α, β, and γ subunits, and PDE6B encodes the β subunit of this protein[1]. cGMP-PDE complexes are present in optic rod photoreceptor cells as part of the photoreceptor tissue at the back of the eye (retina), and the optic rod is specifically responsible for transmitting visual signals from the eye to the brain under low light conditions. When light enters the eye, photon absorption can trigger a signaling cascade in the optic rod photoreceptors that activate cGMP-PDE, leading to rapid cGMP hydrolysis, closure of cGMP-gated cation channels, and cellular hyperpolarization; these changes trigger the closure of channels in the cell membrane, resulting in the transmission of signals to the brain that is referred to as vision. In humans, mutations in the PDE6B gene lead to Retinitis pigmentosa (RP) and congenital stationary night blindness (CSNB) [2].
This strain is a mouse Pde6b knockout model that uses gene editing technology to knock out the homolog of the human PDE6B gene in mice. The deletion of Pde6b gene expression in mice leads to dysfunction of the cGMP-PDE complex and rapid apoptosis of optic rod cell photoreceptors, causing severe retinal degeneration (RD), and the progression of ocular retinal disease in this model is similar to that of mice carrying the RD1 spontaneous mutations in the mouse Pde6b gene[3], which is a class of animal models of early-onset retinal degeneration.
This strain is a mouse Pde6b knockout model that uses gene editing technology to knock out the homolog of the human PDE6B gene in mice. The deletion of Pde6b gene expression in mice leads to dysfunction of the cGMP-PDE complex and rapid apoptosis of optic rod cell photoreceptors, causing severe retinal degeneration (RD), and the progression of ocular retinal disease in this model is similar to that of mice carrying the RD1 spontaneous mutations in the mouse Pde6b gene[3], which is a class of animal models of early-onset retinal degeneration.
Phosphodiesterase 6B (PDE6B) is a protein-coding gene that encodes a protein that is part of the cGMP phosphodiesterase (cGMP-PDE) protein complex, a peripheral membrane isomerase consisting of α, β, and γ subunits, and PDE6B encodes the β subunit of this protein[1]. cGMP-PDE complexes are present in optic rod photoreceptor cells as part of the photoreceptor tissue at the back of the eye (retina), and the optic rod is specifically responsible for transmitting visual signals from the eye to the brain under low light conditions. When light enters the eye, photon absorption can trigger a signaling cascade in the optic rod photoreceptors that activate cGMP-PDE, leading to rapid cGMP hydrolysis, closure of cGMP-gated cation channels, and cellular hyperpolarization; these changes trigger the closure of channels in the cell membrane, resulting in the transmission of signals to the brain that is referred to as vision. In humans, mutations in the PDE6B gene lead to Retinitis pigmentosa (RP) and congenital stationary night blindness (CSNB) [2].
This strain is a mouse Pde6b knockout model that uses gene editing technology to knock out the homolog of the human PDE6B gene in mice. The deletion of Pde6b gene expression in mice leads to dysfunction of the cGMP-PDE complex and rapid apoptosis of optic rod cell photoreceptors, causing severe retinal degeneration (RD), and the progression of ocular retinal disease in this model is similar to that of mice carrying the RD1 spontaneous mutations in the mouse Pde6b gene[3], which is a class of animal models of early-onset retinal degeneration.
This strain is a mouse Pde6b knockout model that uses gene editing technology to knock out the homolog of the human PDE6B gene in mice. The deletion of Pde6b gene expression in mice leads to dysfunction of the cGMP-PDE complex and rapid apoptosis of optic rod cell photoreceptors, causing severe retinal degeneration (RD), and the progression of ocular retinal disease in this model is similar to that of mice carrying the RD1 spontaneous mutations in the mouse Pde6b gene[3], which is a class of animal models of early-onset retinal degeneration.
Cd177-KO
製品ID :
S-KO-18587
系統:
C57BL/6JCya
状況:
説明:
Cd177 is located on chromosome 7 of mice. Nuclease Technology was used to design sgRNA; Cd177 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Cd177 is located on chromosome 7 of mice. Nuclease Technology was used to design sgRNA; Cd177 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Pde6b-KO
製品ID :
S-KO-19014
系統:
C57BL/6JCya
状況:
説明:
Pde6b is located on chromosome 5 of mice. Nuclease Technology was used to design sgRNA; Pde6b knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Pde6b is located on chromosome 5 of mice. Nuclease Technology was used to design sgRNA; Pde6b knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Gcsam-flox
製品ID :
S-CKO-18587
系統:
C57BL/6JCya
状況:
説明:
Gcsam is located on chromosome 16 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Gcsam conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Gcsam is located on chromosome 16 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Gcsam conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Pde6b-flox
製品ID :
S-CKO-04214
系統:
C57BL/6JCya
状況:
説明:
Pde6b is located on chromosome 5 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Pde6b conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Pde6b is located on chromosome 5 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Pde6b conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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