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6 件の結果が “19373” で取得されました
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Rag1 KO
製品ID :
C001197
系統:
C57BL/6NCya
状況:
説明:
The V(D)J recombination activation gene RAG1 was isolated based on its ability to activate V(D)J recombination on an artificial substrate in fibroblasts. This property and the expression pattern in tissues and cell lines indicate that RAG1 either activates or catalyzes the V(D)J recombination reaction of immunoglobulin and T cell receptor genes [1]. Diseases associated with RAG1 include Alpha/Beta T-cell Lymphopenia With Gamma/Delta T-cell Expansion, Severe Cytomegalovirus Infection, Autoimmunity, and Combined Cellular And Humoral Immune Defects With Granulomas [2].
The Rag1-KO Mouse is a RAG1-deficient model that exhibits smaller lymphoid organs and does not contain mature B and T lymphocytes, the arrest of B and T cell differentiation occurs at an early stage and correlates with the inability to perform V(D)J recombination. The homozygote Rag1-KO mice developed normally and were fertile.
The V(D)J recombination activation gene RAG1 was isolated based on its ability to activate V(D)J recombination on an artificial substrate in fibroblasts. This property and the expression pattern in tissues and cell lines indicate that RAG1 either activates or catalyzes the V(D)J recombination reaction of immunoglobulin and T cell receptor genes [1]. Diseases associated with RAG1 include Alpha/Beta T-cell Lymphopenia With Gamma/Delta T-cell Expansion, Severe Cytomegalovirus Infection, Autoimmunity, and Combined Cellular And Humoral Immune Defects With Granulomas [2].
The Rag1-KO Mouse is a RAG1-deficient model that exhibits smaller lymphoid organs and does not contain mature B and T lymphocytes, the arrest of B and T cell differentiation occurs at an early stage and correlates with the inability to perform V(D)J recombination. The homozygote Rag1-KO mice developed normally and were fertile.
huALB/huFcRn/Rag1-KO
製品ID :
C001957
系統:
C57BL/6NCya
状況:
説明:
The huALB/huFcRn/Rag1-KO mouse is an immunodeficient humanized model obtained by mating huALB/huFcRn mice (catalog No.: C001949) with Rag1-KO mice (catalog No.: C001197). This model can be used for in vivo studies of human IgG antibodies and drug development using human serum albumin (HSA) as a carrier, and may contribute to the research on the pharmacokinetics (PK) of human serum albumin.
The huALB/huFcRn/Rag1-KO mouse is an immunodeficient humanized model obtained by mating huALB/huFcRn mice (catalog No.: C001949) with Rag1-KO mice (catalog No.: C001197). This model can be used for in vivo studies of human IgG antibodies and drug development using human serum albumin (HSA) as a carrier, and may contribute to the research on the pharmacokinetics (PK) of human serum albumin.
Ubap1-KO
製品ID :
S-KO-19373
系統:
C57BL/6JCya
状況:
説明:
Ubap1 is located on chromosome 4 of mice. Nuclease Technology was used to design sgRNA; Ubap1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Ubap1 is located on chromosome 4 of mice. Nuclease Technology was used to design sgRNA; Ubap1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rag1-KO
製品ID :
S-KO-24632
系統:
C57BL/6JCya
状況:
説明:
Rag1 is located on chromosome 2 of mice. Nuclease Technology was used to design sgRNA; Rag1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rag1 is located on chromosome 2 of mice. Nuclease Technology was used to design sgRNA; Rag1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rag1-KO
製品ID :
S-KO-03999
系統:
C57BL/6JCya
状況:
説明:
Rag1 is located on chromosome 2 of mice. Nuclease Technology was used to design sgRNA; Rag1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rag1 is located on chromosome 2 of mice. Nuclease Technology was used to design sgRNA; Rag1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rag1-flox
製品ID :
S-CKO-17488
系統:
C57BL/6JCya
状況:
説明:
Rag1 is located on chromosome 2 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Rag1 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rag1 is located on chromosome 2 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Rag1 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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