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4 件の結果が “20265” で取得されました
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Scn1a-KO
製品ID :
C002015
系統:
C57BL/6JCya
状況:
説明:
The SCN1A gene encodes the α subunit of the voltage-gated sodium channel Nav1.1, which plays a critical role in regulating neuronal excitability and synaptic transmission. Loss-of-function mutations in SCN1A are closely associated with various epilepsy syndromes, most notably Dravet syndrome (DS) [1]. SCN1A mutations primarily affect GABAergic inhibitory interneurons, leading to impaired inhibitory neural circuits, disruption of the excitation/inhibition (E/I) balance, and increased epilepsy susceptibility [2].
The Scn1a-KO mouse model was generated by using gene-editing technology to delete exon 2 of the murine Scn1a gene. This strain is homozygous lethal, with heterozygotes also exhibiting premature mortality. It is suitable for antiepileptic drug screening, validation of SCN1A gene therapy strategies, investigation of epileptogenesis, and research on interventions for neuropsychiatric comorbidities.
The SCN1A gene encodes the α subunit of the voltage-gated sodium channel Nav1.1, which plays a critical role in regulating neuronal excitability and synaptic transmission. Loss-of-function mutations in SCN1A are closely associated with various epilepsy syndromes, most notably Dravet syndrome (DS) [1]. SCN1A mutations primarily affect GABAergic inhibitory interneurons, leading to impaired inhibitory neural circuits, disruption of the excitation/inhibition (E/I) balance, and increased epilepsy susceptibility [2].
The Scn1a-KO mouse model was generated by using gene-editing technology to delete exon 2 of the murine Scn1a gene. This strain is homozygous lethal, with heterozygotes also exhibiting premature mortality. It is suitable for antiepileptic drug screening, validation of SCN1A gene therapy strategies, investigation of epileptogenesis, and research on interventions for neuropsychiatric comorbidities.
Spock3-KO
製品ID :
S-KO-20265
系統:
C57BL/6JCya
状況:
説明:
Spock3 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Spock3 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Spock3 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Spock3 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Scn1a-flox
製品ID :
S-CKO-19949
系統:
C57BL/6JCya
状況:
説明:
Scn1a is located on chromosome 2 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Scn1a conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Scn1a is located on chromosome 2 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Scn1a conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Scn1a-KO
製品ID :
S-KO-20859
系統:
C57BL/6JCya
状況:
説明:
Scn1a is located on chromosome 2 of mice. Nuclease Technology will be used to design sgRNA; Scn1a knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Scn1a is located on chromosome 2 of mice. Nuclease Technology will be used to design sgRNA; Scn1a knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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