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Tnni3-Cre
製品ID :
C001562
系統:
C57BL/6JCya
状況:
説明:
Troponin I (TnI), along with Troponin T (TnT) and Troponin C (TnC), forms the troponin complex in striated muscle. TnI, the inhibitory subunit, blocks actin-myosin interactions, facilitating muscle relaxation and providing a calcium-sensitive switch for muscle contraction. The TnI subfamily includes three genes, with TNNI3 encoding cardiac-specific TnI, expressed only in heart muscle [1]. Mutations in TNNI3 cause familial hypertrophic cardiomyopathy type 7 (CMH7) and restrictive cardiomyopathy (RCM). TnI helps diagnose heart failure and ischemic heart disease, and elevated troponin levels indicate acute myocardial injury in moderate/severe COVID-19 patients. In COVID-19-related cardiovascular diseases, elevated troponin correlates with higher mortality risk.
Tnni3-Cre mice were constructed by integrating the Cre-rBG pA gene expression component into the mouse Tnni3 gene by gene editing, a strategy that disrupts the expression of the endogenous Tnni3 gene in mice. When Tnni3-Cre mice are crossed with mice containing loxP sites, sequence recombination mediated by Cre recombinase occurs in the offspring's cardiomyocytes.
Troponin I (TnI), along with Troponin T (TnT) and Troponin C (TnC), forms the troponin complex in striated muscle. TnI, the inhibitory subunit, blocks actin-myosin interactions, facilitating muscle relaxation and providing a calcium-sensitive switch for muscle contraction. The TnI subfamily includes three genes, with TNNI3 encoding cardiac-specific TnI, expressed only in heart muscle [1]. Mutations in TNNI3 cause familial hypertrophic cardiomyopathy type 7 (CMH7) and restrictive cardiomyopathy (RCM). TnI helps diagnose heart failure and ischemic heart disease, and elevated troponin levels indicate acute myocardial injury in moderate/severe COVID-19 patients. In COVID-19-related cardiovascular diseases, elevated troponin correlates with higher mortality risk.
Tnni3-Cre mice were constructed by integrating the Cre-rBG pA gene expression component into the mouse Tnni3 gene by gene editing, a strategy that disrupts the expression of the endogenous Tnni3 gene in mice. When Tnni3-Cre mice are crossed with mice containing loxP sites, sequence recombination mediated by Cre recombinase occurs in the offspring's cardiomyocytes.
Amy1-flox
製品ID :
S-CKO-21954
系統:
C57BL/6JCya
状況:
説明:
Amy1 is located on chromosome 3 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Amy1 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Amy1 is located on chromosome 3 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Amy1 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Tnni3-flox
製品ID :
S-CKO-06402
系統:
C57BL/6JCya
状況:
説明:
Tnni3 is located on chromosome 7 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Tnni3 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Tnni3 is located on chromosome 7 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Tnni3 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Tnni3-KO
製品ID :
S-KO-18741
系統:
C57BL/6JCya
状況:
説明:
Tnni3 is located on chromosome 7 of mice. Nuclease Technology will be used to design sgRNA; Tnni3 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Tnni3 is located on chromosome 7 of mice. Nuclease Technology will be used to design sgRNA; Tnni3 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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