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5 件の結果が “22262” で取得されました
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Uox KO
製品ID :
C001232
系統:
C57BL/6JCya
状況:
説明:
Uricase, which is encoded by the urate oxidase (UOX) gene, has an important role in the purine metabolic pathway, and most mammals contain UOX, which breaks down uric acid, a metabolite of purine nucleotides, into allantoin, which is more soluble than uric acid. Unlike other mammals, humans lack UOX, and purine catabolism can only produce uric acid, which is subsequently excreted by the kidneys, resulting in higher serum uric acid concentrations in humans than in other mammals. When the rate of uric acid production exceeds the excretory capacity of the kidneys, the serum uric acid level increases significantly, resulting in hyperuricemia.UOX can dramatically reduce plasma uric acid levels and treat gout and kidney disease secondary to hyperuricemia, among others [1].
This strain is a uricase-deficient mouse line generated by knocking out the mouse Uox gene. Due to impaired uricase synthesis, these mice spontaneously exhibit a hyperuricemic phenotype. Heterozygous Uox KO mice are viable and fertile. Homozygous Uox KO mice require allopurinol or similar drugs for postnatal survival [2].
Uricase, which is encoded by the urate oxidase (UOX) gene, has an important role in the purine metabolic pathway, and most mammals contain UOX, which breaks down uric acid, a metabolite of purine nucleotides, into allantoin, which is more soluble than uric acid. Unlike other mammals, humans lack UOX, and purine catabolism can only produce uric acid, which is subsequently excreted by the kidneys, resulting in higher serum uric acid concentrations in humans than in other mammals. When the rate of uric acid production exceeds the excretory capacity of the kidneys, the serum uric acid level increases significantly, resulting in hyperuricemia.UOX can dramatically reduce plasma uric acid levels and treat gout and kidney disease secondary to hyperuricemia, among others [1].
This strain is a uricase-deficient mouse line generated by knocking out the mouse Uox gene. Due to impaired uricase synthesis, these mice spontaneously exhibit a hyperuricemic phenotype. Heterozygous Uox KO mice are viable and fertile. Homozygous Uox KO mice require allopurinol or similar drugs for postnatal survival [2].
B6-Uox KO/huXDH
製品ID :
C001938
系統:
C57BL/6Cya
状況:
説明:
The B6-Uox KO/huXDH mice are humanized disease models obtained by mating Uox KO mice (catalog No.: C001232) with B6-huXDH mice (catalog No.: C001586). This model is suitable for studying the pathological mechanisms of hyperuricemia and gout, and provides an ideal preclinical research platform for the development of novel xanthine oxidase inhibitors and small nucleic acid therapies. It is worth noting that heterozygous Uox KO mice can survive and are fertile, while homozygous Uox KO mice require drugs such as Allopurinol to maintain their survival after birth.
The B6-Uox KO/huXDH mice are humanized disease models obtained by mating Uox KO mice (catalog No.: C001232) with B6-huXDH mice (catalog No.: C001586). This model is suitable for studying the pathological mechanisms of hyperuricemia and gout, and provides an ideal preclinical research platform for the development of novel xanthine oxidase inhibitors and small nucleic acid therapies. It is worth noting that heterozygous Uox KO mice can survive and are fertile, while homozygous Uox KO mice require drugs such as Allopurinol to maintain their survival after birth.
B6-Uox KO/huURAT1
製品ID :
C001937
系統:
C57BL/6Cya
状況:
説明:
B6-Uox KO/huURAT1 mice are humanized disease models obtained by crossing Uox KO mice (catalog No.: C001232) with B6-huURAT1 mice (catalog No.: C001704). This model can be used for studying the pathological mechanisms and treatment methods of uric acid metabolism-related diseases such as hyperuricemia and gout, as well as for screening and developing URAT1-targeted therapies and evaluating preclinical efficacy and safety. It is worth noting that heterozygous Uox KO mice can survive and are fertile, while homozygous Uox KO mice need to be maintained with drugs such as Allopurinol after birth.
B6-Uox KO/huURAT1 mice are humanized disease models obtained by crossing Uox KO mice (catalog No.: C001232) with B6-huURAT1 mice (catalog No.: C001704). This model can be used for studying the pathological mechanisms and treatment methods of uric acid metabolism-related diseases such as hyperuricemia and gout, as well as for screening and developing URAT1-targeted therapies and evaluating preclinical efficacy and safety. It is worth noting that heterozygous Uox KO mice can survive and are fertile, while homozygous Uox KO mice need to be maintained with drugs such as Allopurinol after birth.
Uox-flox
製品ID :
S-CKO-06551
系統:
C57BL/6JCya
状況:
説明:
Uox is located on chromosome 3 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Uox conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Uox is located on chromosome 3 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Uox conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Eif4e-flox
製品ID :
S-CKO-22262
系統:
C57BL/6JCya
状況:
説明:
Eif4e is located on chromosome 3 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Eif4e conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Eif4e is located on chromosome 3 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Eif4e conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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