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huIL1B
製品ID :
C001791
系統:
C57BL/6NCya
状況:
説明:
The IL1B gene encodes Interleukin-1 beta (IL-1β), a potent pro-inflammatory cytokine that is a critical mediator of the inflammatory response and innate immunity. Gene expression of IL1B is primarily observed in activated macrophages and monocytes, but also in other immune cells like dendritic cells and even some epithelial cells and keratinocytes [1]. IL-1β is initially synthesized as an inactive precursor protein (pro-IL-1β), which then undergoes proteolytic processing by caspase-1 (CASP1/ICE) within inflammasome complexes to yield its mature, biologically active form. This mature protein plays diverse roles in cellular activities, including cell proliferation, differentiation, apoptosis, and fever generation. It is involved in inducing the production of other inflammatory mediators and activating various immune cells [2]. Aberrant or increased IL-1β expression and activity are associated with a wide range of inflammatory and autoinflammatory diseases, such as Cryopyrin-Associated Periodic Syndromes (CAPS), gout, rheumatoid arthritis (RA), recurrent pericarditis, and type 2 diabetes (T2D). It has also been implicated in various cancers and neurodegenerative conditions [3-4].
The huIL1B mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Il1b gene with the coding sequences of the human IL1B gene. huIL1B mice can be used for research into the pathogenesis of various inflammatory diseases, autoimmune diseases, cancers, and neurodegenerative diseases, as well as for the screening, development, and safety evaluation of IL1B-targeted drugs.
The IL1B gene encodes Interleukin-1 beta (IL-1β), a potent pro-inflammatory cytokine that is a critical mediator of the inflammatory response and innate immunity. Gene expression of IL1B is primarily observed in activated macrophages and monocytes, but also in other immune cells like dendritic cells and even some epithelial cells and keratinocytes [1]. IL-1β is initially synthesized as an inactive precursor protein (pro-IL-1β), which then undergoes proteolytic processing by caspase-1 (CASP1/ICE) within inflammasome complexes to yield its mature, biologically active form. This mature protein plays diverse roles in cellular activities, including cell proliferation, differentiation, apoptosis, and fever generation. It is involved in inducing the production of other inflammatory mediators and activating various immune cells [2]. Aberrant or increased IL-1β expression and activity are associated with a wide range of inflammatory and autoinflammatory diseases, such as Cryopyrin-Associated Periodic Syndromes (CAPS), gout, rheumatoid arthritis (RA), recurrent pericarditis, and type 2 diabetes (T2D). It has also been implicated in various cancers and neurodegenerative conditions [3-4].
The huIL1B mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Il1b gene with the coding sequences of the human IL1B gene. huIL1B mice can be used for research into the pathogenesis of various inflammatory diseases, autoimmune diseases, cancers, and neurodegenerative diseases, as well as for the screening, development, and safety evaluation of IL1B-targeted drugs.
huIL1B/huTFRC
製品ID :
C002028
系統:
C57BL/6NCya
状況:
説明:
Interleukin-1β (IL-1β), encoded by the IL1B gene, is a cytokine with potent pro-inflammatory activity that plays a central role in inflammatory responses and innate immune regulation. It induces the release of various inflammatory mediators and activates immune cells, participating in the regulation of biological processes such as cell proliferation, differentiation, apoptosis, and febrile responses [1-2]. Studies have shown that abnormal expression or activity of IL-1β is closely associated with various pathological processes, including cryopyrin-associated periodic syndromes (CAPS), gout, rheumatoid arthritis (RA), recurrent pericarditis, type 2 diabetes mellitus (T2DM), and other inflammatory and autoimmune diseases, while also playing an important role in the pathogenesis of multiple malignancies and neurodegenerative diseases [3-4]. Transferrin receptor 1 (TFRC) is a transmembrane protein widely expressed across diverse cells and tissues, playing a critical role in iron transport and the maintenance of iron homeostasis. It is highly expressed on brain capillary endothelial cells, making it a vital target for drug delivery across the blood-brain barrier (BBB) [5-6]. In recent years, TFRC-mediated receptor-mediated transcytosis (RMT) has become a key strategy for improving the delivery efficiency of therapeutic antibodies and other macromolecular drugs across the BBB. In neuroinflammatory diseases such as multiple sclerosis (MS), IL-1β can promote microglial activation, induce pathogenic Th17 cell responses, increase BBB permeability, and facilitate the recruitment of inflammatory cells, thereby driving central nervous system inflammation and demyelinating injury [7-8].
The huIL1B/huTFRC mouse is a dual-gene humanized model obtained by crossing the huIL1B mouse (Catalog No.: C001791) with the huTFRC mouse (Catalog No.: C001860). This model can be utilized for the screening, pharmacodynamic evaluation, safety assessment, and mechanism-of-action studies of IL1B/TFRC-targeted drugs. Meanwhile, it is suitable for evaluating the trans-BBB delivery capacity of therapeutic agents, providing an ideal preclinical research platform for the development of innovative therapies for neuroinflammatory diseases, such as multiple sclerosis (MS).
Interleukin-1β (IL-1β), encoded by the IL1B gene, is a cytokine with potent pro-inflammatory activity that plays a central role in inflammatory responses and innate immune regulation. It induces the release of various inflammatory mediators and activates immune cells, participating in the regulation of biological processes such as cell proliferation, differentiation, apoptosis, and febrile responses [1-2]. Studies have shown that abnormal expression or activity of IL-1β is closely associated with various pathological processes, including cryopyrin-associated periodic syndromes (CAPS), gout, rheumatoid arthritis (RA), recurrent pericarditis, type 2 diabetes mellitus (T2DM), and other inflammatory and autoimmune diseases, while also playing an important role in the pathogenesis of multiple malignancies and neurodegenerative diseases [3-4]. Transferrin receptor 1 (TFRC) is a transmembrane protein widely expressed across diverse cells and tissues, playing a critical role in iron transport and the maintenance of iron homeostasis. It is highly expressed on brain capillary endothelial cells, making it a vital target for drug delivery across the blood-brain barrier (BBB) [5-6]. In recent years, TFRC-mediated receptor-mediated transcytosis (RMT) has become a key strategy for improving the delivery efficiency of therapeutic antibodies and other macromolecular drugs across the BBB. In neuroinflammatory diseases such as multiple sclerosis (MS), IL-1β can promote microglial activation, induce pathogenic Th17 cell responses, increase BBB permeability, and facilitate the recruitment of inflammatory cells, thereby driving central nervous system inflammation and demyelinating injury [7-8].
The huIL1B/huTFRC mouse is a dual-gene humanized model obtained by crossing the huIL1B mouse (Catalog No.: C001791) with the huTFRC mouse (Catalog No.: C001860). This model can be utilized for the screening, pharmacodynamic evaluation, safety assessment, and mechanism-of-action studies of IL1B/TFRC-targeted drugs. Meanwhile, it is suitable for evaluating the trans-BBB delivery capacity of therapeutic agents, providing an ideal preclinical research platform for the development of innovative therapies for neuroinflammatory diseases, such as multiple sclerosis (MS).
Amacr-flox
製品ID :
S-CKO-03553
系統:
C57BL/6JCya
状況:
説明:
Amacr is located on chromosome 15 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Amacr conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Amacr is located on chromosome 15 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Amacr conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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