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2 件の結果が “3561” で取得されました
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B6-hIL2RG
製品ID :
C001801
系統:
C57BL/6NCya
状況:
説明:
The IL2RG (Interleukin 2 Receptor Subunit Gamma) gene, located on the X chromosome, provides instructions for making the common gamma chain protein (also known as CD132 or γc). This protein is a critical signaling component shared by the receptors for several interleukins, including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. IL2RG is widely expressed, particularly in lymphoid tissues like the lymph nodes, appendix, thymus, and spleen, as well as in immature blood-forming cells in the bone marrow, and also detected in other tissues such as skin and intestine [1-2]. The common gamma chain is essential for the development, proliferation, and function of various immune cells, including T cells, B cells, and natural killer (NK) cells, by facilitating intracellular signaling pathways such as JAK/STAT, MAPK, and PI3K/AKT, which are crucial for immune system homeostasis [1-2]. Mutations in the IL2RG gene are primarily associated with X-linked severe combined immunodeficiency (X-SCID), a severe inherited disorder causing profound defects in both cellular and humoral immunity, typically affecting males and leading to recurrent, life-threatening infections [3-4]. Less severe "hypomorphic" mutations can cause X-linked combined immunodeficiency (XCID), and IL2RG dysregulation has also been implicated in certain cancers and autoimmune conditions [1].
The B6-hIL2RG mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Il2rg gene with the coding sequences of the human IL2RG gene. B6-hIL2RG mice can be used for research into the pathogenesis of X-linked severe combined immunodeficiency (X-SCID), certain autoimmune diseases, and hematological malignancies, as well as for the screening, development, and safety evaluation of IL2RG-targeted drugs.
The IL2RG (Interleukin 2 Receptor Subunit Gamma) gene, located on the X chromosome, provides instructions for making the common gamma chain protein (also known as CD132 or γc). This protein is a critical signaling component shared by the receptors for several interleukins, including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. IL2RG is widely expressed, particularly in lymphoid tissues like the lymph nodes, appendix, thymus, and spleen, as well as in immature blood-forming cells in the bone marrow, and also detected in other tissues such as skin and intestine [1-2]. The common gamma chain is essential for the development, proliferation, and function of various immune cells, including T cells, B cells, and natural killer (NK) cells, by facilitating intracellular signaling pathways such as JAK/STAT, MAPK, and PI3K/AKT, which are crucial for immune system homeostasis [1-2]. Mutations in the IL2RG gene are primarily associated with X-linked severe combined immunodeficiency (X-SCID), a severe inherited disorder causing profound defects in both cellular and humoral immunity, typically affecting males and leading to recurrent, life-threatening infections [3-4]. Less severe "hypomorphic" mutations can cause X-linked combined immunodeficiency (XCID), and IL2RG dysregulation has also been implicated in certain cancers and autoimmune conditions [1].
The B6-hIL2RG mouse is a humanized model, constructed by replacing the coding sequences of the endogenous mouse Il2rg gene with the coding sequences of the human IL2RG gene. B6-hIL2RG mice can be used for research into the pathogenesis of X-linked severe combined immunodeficiency (X-SCID), certain autoimmune diseases, and hematological malignancies, as well as for the screening, development, and safety evaluation of IL2RG-targeted drugs.
Pax5-KO
製品ID :
S-KO-03561
系統:
C57BL/6JCya
状況:
説明:
Pax5 is located on chromosome 4 of mice. Nuclease Technology was used to design sgRNA; Pax5 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Pax5 is located on chromosome 4 of mice. Nuclease Technology was used to design sgRNA; Pax5 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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