フィルター
4 件の結果が “3567” で取得されました
並べ替える:
アルファベット順（A-Z）
ベストセラー
huIL5
製品ID :
C001813
系統:
C57BL/6NCya
状況:
説明:
Interleukin-5 (IL-5) is a cytokine secreted by Th2 CD4+ T cells, mast cells, and type 2 innate lymphoid cells (ILC2s). It plays a pivotal role in regulating the proliferation, differentiation, activation, and survival of eosinophils [1]. The IL5 gene is located within the 5q31 region of human chromosome 5, clustered alongside other Th2 cytokine genes such as IL4 and IL13, and is co-regulated by transcription factors including GATA3 [2]. By binding to the IL-5 receptor alpha chain (IL-5Rα), IL-5 activates signaling pathways like JAK2-STAT5, thereby modulating eosinophil-associated immune responses [1-2]. Aberrant IL-5 expression is closely linked to various eosinophil-related disorders, including asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), hypereosinophilic syndrome, and allergic rhinitis, making the IL-5/IL-5Rα axis a prominent therapeutic target. Consequently, several antibody drugs targeting IL-5 or IL-5Rα, such as Mepolizumab and Benralizumab, have been approved or are currently under clinical investigation [3-4].
The huIL5 mouse is a humanized model generated by replacing the mouse Il5 gene sequence (from the start codon to the stop codon) with the corresponding human IL5 sequence via in situ substitution. This model is highly valuable for studying eosinophilic diseases (e.g., asthma, CRSwNP, and hypereosinophilic syndrome), allergic inflammatory immune regulation, and Th2 immune responses. Furthermore, it serves as a robust platform for the development of IL-5-targeted therapeutics.
Interleukin-5 (IL-5) is a cytokine secreted by Th2 CD4+ T cells, mast cells, and type 2 innate lymphoid cells (ILC2s). It plays a pivotal role in regulating the proliferation, differentiation, activation, and survival of eosinophils [1]. The IL5 gene is located within the 5q31 region of human chromosome 5, clustered alongside other Th2 cytokine genes such as IL4 and IL13, and is co-regulated by transcription factors including GATA3 [2]. By binding to the IL-5 receptor alpha chain (IL-5Rα), IL-5 activates signaling pathways like JAK2-STAT5, thereby modulating eosinophil-associated immune responses [1-2]. Aberrant IL-5 expression is closely linked to various eosinophil-related disorders, including asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), hypereosinophilic syndrome, and allergic rhinitis, making the IL-5/IL-5Rα axis a prominent therapeutic target. Consequently, several antibody drugs targeting IL-5 or IL-5Rα, such as Mepolizumab and Benralizumab, have been approved or are currently under clinical investigation [3-4].
The huIL5 mouse is a humanized model generated by replacing the mouse Il5 gene sequence (from the start codon to the stop codon) with the corresponding human IL5 sequence via in situ substitution. This model is highly valuable for studying eosinophilic diseases (e.g., asthma, CRSwNP, and hypereosinophilic syndrome), allergic inflammatory immune regulation, and Th2 immune responses. Furthermore, it serves as a robust platform for the development of IL-5-targeted therapeutics.
huIL5/huIL5RA
製品ID :
C002042
系統:
C57BL/6NCya
状況:
説明:
The huIL5/huIL5RA mouse is a dual-gene humanized model obtained by mating huIL5 mice (Catalog No.: C001813) with huIL5RA mice (Catalog No.: C002007). This model is applicable to the screening of human IgG antibody drug candidates, as well as the evaluation of pharmacology, pharmacodynamics, and pharmacokinetics. It serves as a valuable tool for advancing research in immunotherapies for allergic diseases and the mechanisms of Th2-type immune responses.
The huIL5/huIL5RA mouse is a dual-gene humanized model obtained by mating huIL5 mice (Catalog No.: C001813) with huIL5RA mice (Catalog No.: C002007). This model is applicable to the screening of human IgG antibody drug candidates, as well as the evaluation of pharmacology, pharmacodynamics, and pharmacokinetics. It serves as a valuable tool for advancing research in immunotherapies for allergic diseases and the mechanisms of Th2-type immune responses.
Pcdh8-KO
製品ID :
S-KO-03567
系統:
C57BL/6JCya
状況:
説明:
Pcdh8 is located on chromosome 14 of mice. Nuclease Technology will be used to design sgRNA; Pcdh8 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Pcdh8 is located on chromosome 14 of mice. Nuclease Technology will be used to design sgRNA; Pcdh8 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Edaradd-flox
製品ID :
S-CKO-03567
系統:
C57BL/6JCya
状況:
説明:
Edaradd is located on chromosome 13 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Edaradd conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Edaradd is located on chromosome 13 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Edaradd conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Items: 1 to 4 of 4
1