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B6-hIL6ST
製品ID :
C001786
系統:
C57BL/6NCya
状況:
説明:
The IL6ST gene, also known as gp130, encodes a crucial signal-transducing protein that is part of the receptor complex for a wide range of cytokines, including Interleukin-6 (IL-6), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), and oncostatin M (OSM) [1]. This protein is ubiquitously expressed across various cellular tissues, including but not limited to the brain, heart, thymus, spleen, kidney, lung, liver, and endometrial tissues, playing critical roles in mediating signals that regulate immune response, hematopoiesis, pain control, bone metabolism, and embryonic development. Its function involves homodimerization upon cytokine binding to initiate intracellular signaling pathways like JAK-MAPK and JAK-STAT3, thereby influencing cell proliferation, differentiation, and survival [2]. Dysregulation or mutations in IL6ST are associated with several diseases, notably various forms of Hyper-IgE Syndrome (HIES), particularly Hyper-IgE recurrent infection syndrome type 4 (autosomal recessive and dominant forms), as well as playing a role in conditions like rheumatoid arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease, breast cancer, and endometriosis [3-4].
The B6-hIL6ST mouse is a humanized model constructed by replacing the endogenous partial extracellular domain of the mouse Il6st gene with the human IL6ST partial extracellular domain. The murine signal peptide, transmembrane, and cytoplasmic domains are preserved. B6-hIL6ST mice can be used for research into the pathogenesis of inflammatory and autoimmune diseases, as well as certain tumors, and for the screening, development, and safety evaluation of IL6ST-targeted drugs.
The IL6ST gene, also known as gp130, encodes a crucial signal-transducing protein that is part of the receptor complex for a wide range of cytokines, including Interleukin-6 (IL-6), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), and oncostatin M (OSM) [1]. This protein is ubiquitously expressed across various cellular tissues, including but not limited to the brain, heart, thymus, spleen, kidney, lung, liver, and endometrial tissues, playing critical roles in mediating signals that regulate immune response, hematopoiesis, pain control, bone metabolism, and embryonic development. Its function involves homodimerization upon cytokine binding to initiate intracellular signaling pathways like JAK-MAPK and JAK-STAT3, thereby influencing cell proliferation, differentiation, and survival [2]. Dysregulation or mutations in IL6ST are associated with several diseases, notably various forms of Hyper-IgE Syndrome (HIES), particularly Hyper-IgE recurrent infection syndrome type 4 (autosomal recessive and dominant forms), as well as playing a role in conditions like rheumatoid arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease, breast cancer, and endometriosis [3-4].
The B6-hIL6ST mouse is a humanized model constructed by replacing the endogenous partial extracellular domain of the mouse Il6st gene with the human IL6ST partial extracellular domain. The murine signal peptide, transmembrane, and cytoplasmic domains are preserved. B6-hIL6ST mice can be used for research into the pathogenesis of inflammatory and autoimmune diseases, as well as certain tumors, and for the screening, development, and safety evaluation of IL6ST-targeted drugs.
Pcna-KO
製品ID :
S-KO-03572
系統:
C57BL/6JCya
状況:
説明:
Pcna is located on chromosome 2 of mice. Nuclease Technology was used to design sgRNA; Pcna knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Pcna is located on chromosome 2 of mice. Nuclease Technology was used to design sgRNA; Pcna knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Vmn1r228-flox
製品ID :
S-CKO-03572
系統:
C57BL/6JCya
状況:
説明:
Vmn1r228 is located on chromosome 17 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Vmn1r228 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Vmn1r228 is located on chromosome 17 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Vmn1r228 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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