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Clec4f-iCre
製品ID :
C001353
系統:
C57BL/6JCya
状況:
説明:
CLEC4F (C-Type Lectin Domain Family 4 Member F) is a type II transmembrane glycoprotein member of the C-type lectin superfamily. Studies have shown that CLEC4F is a highly glycosylated membrane protein co-expressed with F4/80 on Kupffer cells (KC) and mCLEC4F was detected in the fetal liver at embryonic day 11.5 (E11.5). Kupffer cells are resident macrophages in the liver that participate in iron metabolism and the clearance of gut-derived microbial products.
This strain was constructed using gene editing technology. The “IRES-iCre” cassette was inserted 60~100 bp down stream of the TAG stop codon. When crossed with mice containing loxP sites, the offspring can produce sequence recombination between loxP sites mediated by Cre recombinase in KC cells. The homozygous Clec4f-iCre mice are viable and fertile.
CLEC4F (C-Type Lectin Domain Family 4 Member F) is a type II transmembrane glycoprotein member of the C-type lectin superfamily. Studies have shown that CLEC4F is a highly glycosylated membrane protein co-expressed with F4/80 on Kupffer cells (KC) and mCLEC4F was detected in the fetal liver at embryonic day 11.5 (E11.5). Kupffer cells are resident macrophages in the liver that participate in iron metabolism and the clearance of gut-derived microbial products.
This strain was constructed using gene editing technology. The “IRES-iCre” cassette was inserted 60~100 bp down stream of the TAG stop codon. When crossed with mice containing loxP sites, the offspring can produce sequence recombination between loxP sites mediated by Cre recombinase in KC cells. The homozygous Clec4f-iCre mice are viable and fertile.
Clec4f-KO
製品ID :
S-KO-18602
系統:
C57BL/6JCya
状況:
説明:
Clec4f is located on chromosome 6 of mice. Nuclease Technology was used to design sgRNA; Clec4f knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Clec4f is located on chromosome 6 of mice. Nuclease Technology was used to design sgRNA; Clec4f knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Clec4f-flox
製品ID :
S-CKO-11457
系統:
C57BL/6JCya
状況:
説明:
Clec4f is located on chromosome 6 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Clec4f conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Clec4f is located on chromosome 6 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Clec4f conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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