huNPR1(SD) Rat
製品名
huNPR1(SD) Rat
製品ID
CR010
系統名
SD-Npr1em1(hNPR1)/Cya
背景情報
Sprague-Dawley
状況
このマウス系統を論文で使用する場合は、「huNPR1(SD) Rat（カタログ番号CR010）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子名
遺伝子別名
ANPa, NPRA, ANPRA, GUC2A, GUCY2A
NCBI ID
染色体
Chr 1
MGI ID
--
さらに
系統詳細
The human NPR1 gene, also known as natriuretic peptide receptor 1 or guanylyl cyclase-A (GC-A), encodes for a transmembrane receptor called natriuretic peptide receptor-A (NPRA). This protein acts as a cell-surface receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), two key hormones that regulate cardiovascular homeostasis [1]. Upon binding, NPRA catalyzes the conversion of GTP to the second messenger cyclic GMP (cGMP), leading to vasodilation, natriuresis (increased sodium excretion), diuresis (increased urine production), and protection against cardiac remodeling [1-2]. The NPR1 gene is expressed in various cellular tissues, including the heart, kidneys, vascular smooth muscle, and immune cells. Genetic variations and altered expression of NPR1 are associated with several cardiovascular diseases, including essential hypertension, left ventricular hypertrophy, congestive heart failure, and coronary artery disease [3]. Alterations in NPRA expression have also been linked to certain cancers, such as gastric cancer, and metabolic disorders [4].
huNPR1(SD) rats are a humanized model generated using gene editing technology, in which the rat Npr1 endogenous extracellular domain is replaced with the human NPR1 extracellular domain. huNPR1(SD) rats can be used for studying the pathological mechanisms and therapeutic approaches for several cardiovascular diseases, including essential hypertension, left ventricular hypertrophy, congestive heart failure, and coronary artery disease, as well as specific cancers. They are also useful for the development of NPR1-targeted drugs.
参考文献
Misono KS, Philo JS, Arakawa T, Ogata CM, Qiu Y, Ogawa H, Young HS. Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase. FEBS J. 2011 Jun;278(11):1818-29.
Hubers SA, Schirger JA, Sangaralingham SJ, Chen Y, Burnett JC Jr, Hodge D, Chen HH. B-type natriuretic peptide and cardiac remodelling after myocardial infarction: a randomised trial. Heart. 2021 Mar;107(5):396-402.
Vandenwijngaert S, Ledsky CD, Lahrouchi N, Khan MAF, Wunderer F, Ames L, Honda T, Diener JL, Bezzina CR, Buys ES, Bloch DB, Newton-Cheh C; CHARGE+ Exome Chip Blood Pressure Consortium, the CHD Exome+ Consortium, the Exome BP Consortium, the GoT2D Consortium, the T2D-GENES Consortium and the UK Biobank CardioMetabolic Consortium BP Working Group. Blood Pressure-Associated Genetic Variants in the Natriuretic Peptide Receptor 1 Gene Modulate Guanylate Cyclase Activity. Circ Genom Precis Med. 2019 Aug;12(8):e002472.
Cao T, Wang S, Qian L, Wu C, Huang T, Wang Y, Li Q, Wang J, Xia Y, Xu L, Wang L, Huang X. NPRA promotes fatty acid metabolism and proliferation of gastric cancer cells by binding to PPARα. Transl Oncol. 2023 Sep;35:101734.
系統作製戦略
The rat Npr1 endogenous extracellular domain was replaced with the human NPR1 extracellular domain.
Figure 1. Gene editing strategy for huNPR1(SD) rats.
適用分野
NPR1-targeted drug screening, development, and evaluation;
Research on the pathological mechanisms and therapeutic approaches of several cardiovascular diseases, including essential hypertension, left ventricular hypertrophy, congestive heart failure, and coronary artery disease;
Research on the pathological mechanisms and therapeutic approaches of specific cancers.
お問い合わせ
カスタムの動物モデルに関するご相談は、下記のフォームにご記入いただき、ご連絡いただくか見積もりをご依頼ください。
Cyagenはお客様のプライバシーを大変重視しています。当社の最新の製品や情報をお届けしたいと思っています。お客様の設定をご確認ください。
これらの配信はいつでも解除できます。配信停止方法およびデータ保護の詳細は プライバシーポリシー をご確認ください。
以下のボタンをクリックすることで、このフォームにご入力いただいた個人情報をCyagenが保存・処理し、ご要望のコンテンツを提供することに同意されたことになります。