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huNPR1(SD)
製品ID :
CR010
系統:
Sprague-Dawley
状況:
説明:
The human NPR1 gene, also known as natriuretic peptide receptor 1 or guanylyl cyclase-A (GC-A), encodes for a transmembrane receptor called natriuretic peptide receptor-A (NPRA). This protein acts as a cell-surface receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), two key hormones that regulate cardiovascular homeostasis [1]. Upon binding, NPRA catalyzes the conversion of GTP to the second messenger cyclic GMP (cGMP), leading to vasodilation, natriuresis (increased sodium excretion), diuresis (increased urine production), and protection against cardiac remodeling [1-2]. The NPR1 gene is expressed in various cellular tissues, including the heart, kidneys, vascular smooth muscle, and immune cells. Genetic variations and altered expression of NPR1 are associated with several cardiovascular diseases, including essential hypertension, left ventricular hypertrophy, congestive heart failure, and coronary artery disease [3]. Alterations in NPRA expression have also been linked to certain cancers, such as gastric cancer, and metabolic disorders [4].
huNPR1(SD) rats are a humanized model generated using gene editing technology, in which the rat Npr1 endogenous extracellular domain is replaced with the human NPR1 extracellular domain. huNPR1(SD) rats can be used for studying the pathological mechanisms and therapeutic approaches for several cardiovascular diseases, including essential hypertension, left ventricular hypertrophy, congestive heart failure, and coronary artery disease, as well as specific cancers. They are also useful for the development of NPR1-targeted drugs.
The human NPR1 gene, also known as natriuretic peptide receptor 1 or guanylyl cyclase-A (GC-A), encodes for a transmembrane receptor called natriuretic peptide receptor-A (NPRA). This protein acts as a cell-surface receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), two key hormones that regulate cardiovascular homeostasis [1]. Upon binding, NPRA catalyzes the conversion of GTP to the second messenger cyclic GMP (cGMP), leading to vasodilation, natriuresis (increased sodium excretion), diuresis (increased urine production), and protection against cardiac remodeling [1-2]. The NPR1 gene is expressed in various cellular tissues, including the heart, kidneys, vascular smooth muscle, and immune cells. Genetic variations and altered expression of NPR1 are associated with several cardiovascular diseases, including essential hypertension, left ventricular hypertrophy, congestive heart failure, and coronary artery disease [3]. Alterations in NPRA expression have also been linked to certain cancers, such as gastric cancer, and metabolic disorders [4].
huNPR1(SD) rats are a humanized model generated using gene editing technology, in which the rat Npr1 endogenous extracellular domain is replaced with the human NPR1 extracellular domain. huNPR1(SD) rats can be used for studying the pathological mechanisms and therapeutic approaches for several cardiovascular diseases, including essential hypertension, left ventricular hypertrophy, congestive heart failure, and coronary artery disease, as well as specific cancers. They are also useful for the development of NPR1-targeted drugs.
Tnpo2-KO
製品ID :
S-KO-04881
系統:
C57BL/6JCya
状況:
説明:
Tnpo2 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Tnpo2 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Tnpo2 is located on chromosome 8 of mice. Nuclease Technology will be used to design sgRNA; Tnpo2 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rtn2-flox
製品ID :
S-CKO-04881
系統:
C57BL/6JCya
状況:
説明:
Rtn2 is located on chromosome 7 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Rtn2 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Rtn2 is located on chromosome 7 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Rtn2 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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