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5 件の結果が “16159” で取得されました
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Il12a KO
製品ID :
C001213
系統:
C57BL/6NCya
状況:
説明:
The interleukin 12A (IL12A or IL12p35) gene encodes the subunits of cytokines IL-12 and IL-35, which act on T cells and natural killer (NK) cells and have extensive biological activity. IL-12 is a heterodimer composed of the p35 subunit encoded by the IL12A gene and the p40 subunit, a member of the cytokine receptor family encoded by the IL12B gene. It is essential for non-T cell-dependent interferon-gamma (IFN-γ) induction and is also crucial for the differentiation of helper T cells (Th1 and Th2). On the other hand, the primary function of IL-35 is to suppress the inflammatory response of immune cells. IL12A also affects cardiovascular diseases by regulating inflammation, including heart fibrosis and myocardial infarction. Mutations in the IL12A gene are associated with susceptibility to certain infectious and autoimmune diseases[1].
This model is an Il12a gene knockout mouse, created using gene-editing technology to knock out the homologous Il12a gene of the human IL12A gene in mice. According to the literature, the deletion of Il12a in this mouse model leads to the loss of the biological effects of IL-12 and IL-35, reduced NK cell responses, altered differentiation of effector T cells, and increased susceptibility to parasitic infections. Additionally, this model cannot exhibit delayed-type hypersensitivity (DTH) reactions induced by the interaction of effector T cells with antigens[2]. The homozygous mice are viable and fertile.
This model is an Il12a gene knockout mouse, created using gene-editing technology to knock out the homologous Il12a gene of the human IL12A gene in mice. According to the literature, the deletion of Il12a in this mouse model leads to the loss of the biological effects of IL-12 and IL-35, reduced NK cell responses, altered differentiation of effector T cells, and increased susceptibility to parasitic infections. Additionally, this model cannot exhibit delayed-type hypersensitivity (DTH) reactions induced by the interaction of effector T cells with antigens[2]. The homozygous mice are viable and fertile.
The interleukin 12A (IL12A or IL12p35) gene encodes the subunits of cytokines IL-12 and IL-35, which act on T cells and natural killer (NK) cells and have extensive biological activity. IL-12 is a heterodimer composed of the p35 subunit encoded by the IL12A gene and the p40 subunit, a member of the cytokine receptor family encoded by the IL12B gene. It is essential for non-T cell-dependent interferon-gamma (IFN-γ) induction and is also crucial for the differentiation of helper T cells (Th1 and Th2). On the other hand, the primary function of IL-35 is to suppress the inflammatory response of immune cells. IL12A also affects cardiovascular diseases by regulating inflammation, including heart fibrosis and myocardial infarction. Mutations in the IL12A gene are associated with susceptibility to certain infectious and autoimmune diseases[1].
This model is an Il12a gene knockout mouse, created using gene-editing technology to knock out the homologous Il12a gene of the human IL12A gene in mice. According to the literature, the deletion of Il12a in this mouse model leads to the loss of the biological effects of IL-12 and IL-35, reduced NK cell responses, altered differentiation of effector T cells, and increased susceptibility to parasitic infections. Additionally, this model cannot exhibit delayed-type hypersensitivity (DTH) reactions induced by the interaction of effector T cells with antigens[2]. The homozygous mice are viable and fertile.
This model is an Il12a gene knockout mouse, created using gene-editing technology to knock out the homologous Il12a gene of the human IL12A gene in mice. According to the literature, the deletion of Il12a in this mouse model leads to the loss of the biological effects of IL-12 and IL-35, reduced NK cell responses, altered differentiation of effector T cells, and increased susceptibility to parasitic infections. Additionally, this model cannot exhibit delayed-type hypersensitivity (DTH) reactions induced by the interaction of effector T cells with antigens[2]. The homozygous mice are viable and fertile.
Lysmd4-flox
製品ID :
S-CKO-16159
系統:
C57BL/6JCya
状況:
説明:
Lysmd4 is located on chromosome 7 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Lysmd4 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Lysmd4 is located on chromosome 7 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Lysmd4 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il12a-KO
製品ID :
S-KO-16759
系統:
C57BL/6JCya
状況:
説明:
Il12a is located on chromosome 3 of mice. Nuclease Technology was used to design sgRNA; Il12a knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il12a is located on chromosome 3 of mice. Nuclease Technology was used to design sgRNA; Il12a knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Aqp1-KO
製品ID :
S-KO-16159
系統:
C57BL/6NCya
状況:
説明:
Aqp1 is located on chromosome 6 of mice. Nuclease Technology was used to design sgRNA; Aqp1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Aqp1 is located on chromosome 6 of mice. Nuclease Technology was used to design sgRNA; Aqp1 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il12a-flox
製品ID :
S-CKO-03078
系統:
C57BL/6JCya
状況:
説明:
Il12a is located on chromosome 3 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Il12a conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il12a is located on chromosome 3 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Il12a conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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