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5 件の結果が “16189” で取得されました
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Il4 KO
製品ID :
C001818
系統:
C57BL/6JCya
状況:
説明:
The IL4 gene encodes interleukin-4 (IL-4), a multifunctional cytokine primarily secreted by Th2 cells, mast cells, and eosinophils. IL-4 promotes Th2 cell differentiation, B cell class switching to IgE, and alternative activation of macrophages (M2 polarization), playing critical roles in allergic responses, anti-parasitic immunity, and tissue repair. IL-4 and its receptor IL-4R are key regulators of immune responses and inflammation; dysregulation of this pathway is associated with various pathologies, including allergic diseases (e.g., asthma, atopic dermatitis, allergic rhinitis), parasitic infections, and certain cancers [1-5].
The Il4 KO mouse, a gene knockout model generated by deleting exons 1–4 of the murine Il4 gene (homologous to human IL4), serves as a valuable tool for investigating the pathogenesis of allergic disorders (e.g., asthma, atopic dermatitis, allergic rhinitis), anti-parasitic immunity, and specific cancers, as well as for developing related therapeutic strategies.
The IL4 gene encodes interleukin-4 (IL-4), a multifunctional cytokine primarily secreted by Th2 cells, mast cells, and eosinophils. IL-4 promotes Th2 cell differentiation, B cell class switching to IgE, and alternative activation of macrophages (M2 polarization), playing critical roles in allergic responses, anti-parasitic immunity, and tissue repair. IL-4 and its receptor IL-4R are key regulators of immune responses and inflammation; dysregulation of this pathway is associated with various pathologies, including allergic diseases (e.g., asthma, atopic dermatitis, allergic rhinitis), parasitic infections, and certain cancers [1-5].
The Il4 KO mouse, a gene knockout model generated by deleting exons 1–4 of the murine Il4 gene (homologous to human IL4), serves as a valuable tool for investigating the pathogenesis of allergic disorders (e.g., asthma, atopic dermatitis, allergic rhinitis), anti-parasitic immunity, and specific cancers, as well as for developing related therapeutic strategies.
Il4-KO
製品ID :
S-KO-02648
系統:
C57BL/6JCya
状況:
説明:
Il4 is located on chromosome 11 of mice. Nuclease Technology will be used to design sgRNA; Il4 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il4 is located on chromosome 11 of mice. Nuclease Technology will be used to design sgRNA; Il4 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Il4-flox
製品ID :
S-CKO-03104
系統:
C57BL/6JCya
状況:
説明:
Il4 is located on chromosome 11 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Il4 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Il4 is located on chromosome 11 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Il4 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Ppp1r1c-flox
製品ID :
S-CKO-16189
系統:
C57BL/6JCya
状況:
説明:
Ppp1r1c is located on chromosome 2 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Ppp1r1c conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Ppp1r1c is located on chromosome 2 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Ppp1r1c conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Ghrl-KO
製品ID :
S-KO-16189
系統:
C57BL/6JCya
状況:
説明:
Ghrl is located on chromosome 6 of mice. Nuclease Technology was used to design sgRNA; Ghrl knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Ghrl is located on chromosome 6 of mice. Nuclease Technology was used to design sgRNA; Ghrl knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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