Il4 KO Mouse
製品名
Il4 KO Mouse
製品ID
C001818
系統名
C57BL/6JCya-Il4em1/Cya
背景情報
C57BL/6JCya
状況
このマウス系統を論文で使用する場合は、「Il4 KO Mouse（カタログ番号C001818）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子名
遺伝子別名
Il-4, BSF-1
NCBI ID
染色体
Chr 11
MGI ID
さらに
系統詳細
The IL4 gene encodes interleukin-4 (IL-4), a multifunctional cytokine primarily secreted by Th2 cells, mast cells, and eosinophils. IL-4 promotes Th2 cell differentiation, B cell class switching to IgE, and alternative activation of macrophages (M2 polarization), playing critical roles in allergic responses, anti-parasitic immunity, and tissue repair. IL-4 and its receptor IL-4R are key regulators of immune responses and inflammation; dysregulation of this pathway is associated with various pathologies, including allergic diseases (e.g., asthma, atopic dermatitis, allergic rhinitis), parasitic infections, and certain cancers [1-5].
The Il4 KO mouse, a gene knockout model generated by deleting exons 1–4 of the murine Il4 gene (homologous to human IL4), serves as a valuable tool for investigating the pathogenesis of allergic disorders (e.g., asthma, atopic dermatitis, allergic rhinitis), anti-parasitic immunity, and specific cancers, as well as for developing related therapeutic strategies.
参考文献
Gandhi NA, Bennett BL, Graham NM, Pirozzi G, Stahl N, Yancopoulos GD. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov. 2016 Jan;15(1):35-50.
Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS. Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. Cell. 2017 Sep 21;171(1):217-228.e13.
Bankaitis KV, Fingleton B. Targeting IL4/IL4R for the treatment of epithelial cancer metastasis. Clin Exp Metastasis. 2015 Dec;32(8):847-56.
Davoodi P, Mahesh PA, Holla AD, Ramachandra NB. A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4Rα) & Toll-like receptor 4 (TLR4) genes with asthma in Indian adults. Indian J Med Res. 2015 Dec;142(6):675-80.
Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, Jia G, Ohri CM, Doran E, Vannella KM, Butler CA, Hargadon B, Sciurba JC, Gieseck RL, Thompson RW, White S, Abbas AR, Jackman J, Wu LC, Egen JG, Heaney LG, Ramalingam TR, Arron JR, Wynn TA, Bradding P. TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma. Sci Transl Med. 2015 Aug 19;7(301):301ra129.
系統作製戦略
The mouse Il4 gene consists of 4 exons, with the ATG start codon in exon 1 and the TAG stop codon in exon 4. This strain was generated by deleting the region spanning exons 1–4 via genome editing.
Figure 1. Diagram of the gene editing strategy for the generation of Il4 KO mice.
適用分野
Pathogenesis and therapeutic evaluation of allergic diseases (e.g., asthma, atopic dermatitis, allergic rhinitis);
Construction of anti-parasitic infection models and dissection of defense mechanisms;
Regulatory mechanisms of Th1/Th2 immune balance;
Modulation of tumor immune microenvironment and development of immunotherapeutic strategies.
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