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Rdh8-KO
製品ID :
C001969
系統:
C57BL/6JCya
状況:
説明:
The RDH8 gene encodes a member of the short-chain dehydrogenase/reductase (SDR) family known as retinol dehydrogenase 8 (or photoreceptor-specific all-trans-retinol dehydrogenase). This protein is primarily expressed in the retina, specifically localized to the outer segments of rod and cone photoreceptor cells, where it acts as the major dehydrogenase responsible for clearing all-trans-retinal. Its primary function is to catalyze the NADPH-dependent reduction of all-trans-retinal to all-trans-retinol, a critical and rate-limiting step in the visual (retinoid) cycle that prevents the accumulation of toxic retinal aldehydes [1]. While RDH8 works alongside RDH12 and ABCA4 to maintain retinal health, its dysfunction is significantly linked to Stargardt macular dystrophy (specifically STGD5) and Age-Related Macular Degeneration (AMD). Recent clinical research has identified specific biallelic splicing variants in RDH8 that lead to progressive macular atrophy, and studies in Abca4-/-Rdh8-/- animal models continue to reveal how the failure of this gene triggers inflammatory stress responses and ferroptosis (a type of programmed cell death) in the neural retina [2].
Rdh8-KO mice are a gene knockout (KO) model in which exons 1-6 of the Rdh8 gene in mice have been knocked out using gene-editing technology. This model can be used to study the pathogenic mechanisms of diseases such as Stargardt macular dystrophy type 5 (STGD5) and age-related macular degeneration (AMD), as well as for the development of relevant treatment methods.
The RDH8 gene encodes a member of the short-chain dehydrogenase/reductase (SDR) family known as retinol dehydrogenase 8 (or photoreceptor-specific all-trans-retinol dehydrogenase). This protein is primarily expressed in the retina, specifically localized to the outer segments of rod and cone photoreceptor cells, where it acts as the major dehydrogenase responsible for clearing all-trans-retinal. Its primary function is to catalyze the NADPH-dependent reduction of all-trans-retinal to all-trans-retinol, a critical and rate-limiting step in the visual (retinoid) cycle that prevents the accumulation of toxic retinal aldehydes [1]. While RDH8 works alongside RDH12 and ABCA4 to maintain retinal health, its dysfunction is significantly linked to Stargardt macular dystrophy (specifically STGD5) and Age-Related Macular Degeneration (AMD). Recent clinical research has identified specific biallelic splicing variants in RDH8 that lead to progressive macular atrophy, and studies in Abca4-/-Rdh8-/- animal models continue to reveal how the failure of this gene triggers inflammatory stress responses and ferroptosis (a type of programmed cell death) in the neural retina [2].
Rdh8-KO mice are a gene knockout (KO) model in which exons 1-6 of the Rdh8 gene in mice have been knocked out using gene-editing technology. This model can be used to study the pathogenic mechanisms of diseases such as Stargardt macular dystrophy type 5 (STGD5) and age-related macular degeneration (AMD), as well as for the development of relevant treatment methods.
Rdh8/Rdh12-DKO
製品ID :
C001967
系統:
C57BL/6JCya
状況:
説明:
The Rdh8/Rdh12-DKO mouse is a dual-gene knockout model obtained by mating Rdh8-KO mice (catalog No.: C001969) with Rdh12-KO mice (catalog No.: C001884). This model can be used for studying the pathogenic mechanisms of Leber Congenital Amaurosis (LCA) and other severe, early-onset retinal degenerations. Furthermore, it provides a robust platform for evaluating therapeutic interventions, particularly in assessing the synergistic effects of multi-gene therapies.
The Rdh8/Rdh12-DKO mouse is a dual-gene knockout model obtained by mating Rdh8-KO mice (catalog No.: C001969) with Rdh12-KO mice (catalog No.: C001884). This model can be used for studying the pathogenic mechanisms of Leber Congenital Amaurosis (LCA) and other severe, early-onset retinal degenerations. Furthermore, it provides a robust platform for evaluating therapeutic interventions, particularly in assessing the synergistic effects of multi-gene therapies.
Abca4/Rdh8-DKO
製品ID :
C001968
系統:
C57BL/6JCya
状況:
説明:
The Abca4/Rdh8-DKO mouse is a dual-gene knockout model obtained by mating Rdh8-KO mice (catalog No.: C001969) with Abca4-KO mice (catalog No.: C002024). This model can be used to investigate the pathogenic mechanisms and therapeutic strategies of diseases, including Stargardt disease (STGD) and age‑related macular degeneration (AMD), and facilitates the evaluation of synergistic effects of polygenic therapies.
The Abca4/Rdh8-DKO mouse is a dual-gene knockout model obtained by mating Rdh8-KO mice (catalog No.: C001969) with Abca4-KO mice (catalog No.: C002024). This model can be used to investigate the pathogenic mechanisms and therapeutic strategies of diseases, including Stargardt disease (STGD) and age‑related macular degeneration (AMD), and facilitates the evaluation of synergistic effects of polygenic therapies.
Rdh8-KO
製品ID :
S-KO-17635
系統:
C57BL/6JCya
状況:
説明:
Rdh8 is located on chromosome 9 of mice. Nuclease Technology was used to design sgRNA; Rdh8 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rdh8 is located on chromosome 9 of mice. Nuclease Technology was used to design sgRNA; Rdh8 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rdh8-flox
製品ID :
S-CKO-07792
系統:
C57BL/6JCya
状況:
説明:
Rdh8 is located on chromosome 9 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Rdh8 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rdh8 is located on chromosome 9 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Rdh8 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rdh8-KO
製品ID :
S-KO-06768
系統:
C57BL/6NCya
状況:
説明:
Rdh8 is located on chromosome 9 of mice. Nuclease Technology will be used to design sgRNA; Rdh8 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rdh8 is located on chromosome 9 of mice. Nuclease Technology will be used to design sgRNA; Rdh8 knockout mice will be obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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