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Alb-cre+/MYC+
製品ID :
C001339
系統:
C57BL/6JCya
状況:
説明:
The MYC oncogene family comprises regulatory genes and proto-oncogenes that encode transcription factors, involved in various cellular processes such as the cell cycle, apoptosis, DNA repair, and metabolism. Members include c-Myc (MYC), l-Myc (MYCL), and n-Myc (MYCN). c-Myc (MYC) is a basic helix-loop-helix leucine zipper (bHLHZip) transcription factor, which forms heterodimers with Max protein to bind DNA and regulate the expression of approximately 15% of genes, thereby participating in key cellular processes such as cell proliferation, apoptosis, DNA repair, and metabolism. In many cancers, c-Myc is overexpressed, leading to uncontrolled cell proliferation and tumor growth, such as in Burkitt's lymphoma where c-Myc gene rearrangement is common. Dysregulation of the MYC oncogene plays a crucial role in tumorigenesis, predominantly through transcriptional dysregulation resulting in overexpression of c-Myc protein.
Alb-Cre+/MYC+ mice are generated by crossing H11-CAG-LSL-hMYC-IRES-EGFP mice (Catalog Number: C001338), which conditionally express the human c-Myc oncogene, with Alb-Cre mice that express Cre recombinase specifically in hepatocytes under the control of the Alb promoter. The Cre-mediated recombination results in the deletion of the transcriptional stop sequence (Loxp-Stop-Loxp, LSL) in H11-CAG-LSL-hMYC-IRES-EGFP mice, leading to overexpression of the MYC oncogene in the liver and subsequent carcinogenesis. This model, therefore, spontaneously develops liver cancer with an early onset.
The MYC oncogene family comprises regulatory genes and proto-oncogenes that encode transcription factors, involved in various cellular processes such as the cell cycle, apoptosis, DNA repair, and metabolism. Members include c-Myc (MYC), l-Myc (MYCL), and n-Myc (MYCN). c-Myc (MYC) is a basic helix-loop-helix leucine zipper (bHLHZip) transcription factor, which forms heterodimers with Max protein to bind DNA and regulate the expression of approximately 15% of genes, thereby participating in key cellular processes such as cell proliferation, apoptosis, DNA repair, and metabolism. In many cancers, c-Myc is overexpressed, leading to uncontrolled cell proliferation and tumor growth, such as in Burkitt's lymphoma where c-Myc gene rearrangement is common. Dysregulation of the MYC oncogene plays a crucial role in tumorigenesis, predominantly through transcriptional dysregulation resulting in overexpression of c-Myc protein.
Alb-Cre+/MYC+ mice are generated by crossing H11-CAG-LSL-hMYC-IRES-EGFP mice (Catalog Number: C001338), which conditionally express the human c-Myc oncogene, with Alb-Cre mice that express Cre recombinase specifically in hepatocytes under the control of the Alb promoter. The Cre-mediated recombination results in the deletion of the transcriptional stop sequence (Loxp-Stop-Loxp, LSL) in H11-CAG-LSL-hMYC-IRES-EGFP mice, leading to overexpression of the MYC oncogene in the liver and subsequent carcinogenesis. This model, therefore, spontaneously develops liver cancer with an early onset.
H11-CAG-LSL-hMYC-IRES-EGFP
製品ID :
C001338
系統:
C57BL/6JCya
状況:
説明:
The MYC gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis, and cellular transformation. The MYC protein forms a heterodimer with the related transcription factor MAX, this complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of the MYC gene is frequently observed in numerous human cancers, MYC protein regulates the expression of a variety of genes related to cell proliferation and metabolic processes, and the MYC gene is also the most common high-abundance oncogene in human cancers. Translocations involving the MYC gene are associated with Burkitt lymphoma and multiple myeloma in human patients [1-3]. The H11 safe harbor locus is located on mouse chromosome 11 and is capable of integrating exogenous genes driven by a designated promoter for stable expression. This strain carries a CAG promoter-driven LSL-hMYC-IRES-EGFP conditional overexpression structure inserted at the H11 safe harbor locus and overexpresses the human MYC gene in specific tissues or cells after mating with tissue-specific Cre mice.
The MYC gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis, and cellular transformation. The MYC protein forms a heterodimer with the related transcription factor MAX, this complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of the MYC gene is frequently observed in numerous human cancers, MYC protein regulates the expression of a variety of genes related to cell proliferation and metabolic processes, and the MYC gene is also the most common high-abundance oncogene in human cancers. Translocations involving the MYC gene are associated with Burkitt lymphoma and multiple myeloma in human patients [1-3]. The H11 safe harbor locus is located on mouse chromosome 11 and is capable of integrating exogenous genes driven by a designated promoter for stable expression. This strain carries a CAG promoter-driven LSL-hMYC-IRES-EGFP conditional overexpression structure inserted at the H11 safe harbor locus and overexpresses the human MYC gene in specific tissues or cells after mating with tissue-specific Cre mice.
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