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Rdh12-KO
製品ID :
C001884
系統:
C57BL/6JCya
状況:
説明:
Rdh12, also known as Retinol dehydrogenase 12, is an NADPH-dependent retinal reductase that is mainly expressed in the inner segments of photoreceptor cells. Rdh12 plays a crucial role in the visual cycle, which is a series of enzymatic reactions essential for the regeneration of visual pigments and is involved in the detoxification process of retinal aldehyde. Mutations in Rdh12 can lead to the degeneration of retinal photoreceptor cells, thereby affecting visual function. The mutations cause a decrease or loss of enzymatic activity in the retina, which in turn affects the progress of the visual cycle and hinders the regeneration of visual pigments. In addition, the mutations may also lead to the accumulation of retinal aldehyde, further damaging the retinal photoreceptor cells [1]. These factors act together, resulting in the degeneration of retinal photoreceptor cells and the loss of visual function. Mutations in Rdh12 are associated with Leber congenital amaurosis (LCA) and autosomal dominant retinitis pigmentosa (RP) [2].
The Rdh12-KO mouse is a knockout (KO) model in which exons 2-5 of the Rdh12 gene in mice are knocked out using gene-editing technology. This model can be used for the research on the pathogenic mechanisms of retinal diseases such as Leber congenital amaurosis (LCA) and autosomal dominant retinitis pigmentosa (RP) and the development of related treatment methods.
Rdh12, also known as Retinol dehydrogenase 12, is an NADPH-dependent retinal reductase that is mainly expressed in the inner segments of photoreceptor cells. Rdh12 plays a crucial role in the visual cycle, which is a series of enzymatic reactions essential for the regeneration of visual pigments and is involved in the detoxification process of retinal aldehyde. Mutations in Rdh12 can lead to the degeneration of retinal photoreceptor cells, thereby affecting visual function. The mutations cause a decrease or loss of enzymatic activity in the retina, which in turn affects the progress of the visual cycle and hinders the regeneration of visual pigments. In addition, the mutations may also lead to the accumulation of retinal aldehyde, further damaging the retinal photoreceptor cells [1]. These factors act together, resulting in the degeneration of retinal photoreceptor cells and the loss of visual function. Mutations in Rdh12 are associated with Leber congenital amaurosis (LCA) and autosomal dominant retinitis pigmentosa (RP) [2].
The Rdh12-KO mouse is a knockout (KO) model in which exons 2-5 of the Rdh12 gene in mice are knocked out using gene-editing technology. This model can be used for the research on the pathogenic mechanisms of retinal diseases such as Leber congenital amaurosis (LCA) and autosomal dominant retinitis pigmentosa (RP) and the development of related treatment methods.
Rdh8/Rdh12-DKO
製品ID :
C001967
系統:
C57BL/6JCya
状況:
説明:
The Rdh8/Rdh12-DKO mouse is a dual-gene knockout model obtained by mating Rdh8-KO mice (catalog No.: C001969) with Rdh12-KO mice (catalog No.: C001884). This model can be used for studying the pathogenic mechanisms of Leber Congenital Amaurosis (LCA) and other severe, early-onset retinal degenerations. Furthermore, it provides a robust platform for evaluating therapeutic interventions, particularly in assessing the synergistic effects of multi-gene therapies.
The Rdh8/Rdh12-DKO mouse is a dual-gene knockout model obtained by mating Rdh8-KO mice (catalog No.: C001969) with Rdh12-KO mice (catalog No.: C001884). This model can be used for studying the pathogenic mechanisms of Leber Congenital Amaurosis (LCA) and other severe, early-onset retinal degenerations. Furthermore, it provides a robust platform for evaluating therapeutic interventions, particularly in assessing the synergistic effects of multi-gene therapies.
Rdh12-KO
製品ID :
S-KO-17646
系統:
C57BL/6JCya
状況:
説明:
Rdh12 is located on chromosome 12 of mice. Nuclease Technology was used to design sgRNA; Rdh12 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rdh12 is located on chromosome 12 of mice. Nuclease Technology was used to design sgRNA; Rdh12 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rdh12-KO
製品ID :
S-KO-15115
系統:
C57BL/6NCya
状況:
説明:
Rdh12 is located on chromosome 12 of mice. Nuclease Technology was used to design sgRNA; Rdh12 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rdh12 is located on chromosome 12 of mice. Nuclease Technology was used to design sgRNA; Rdh12 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rdh12-flox
製品ID :
S-CKO-16750
系統:
C57BL/6JCya
状況:
説明:
Rdh12 is located on chromosome 12 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Rdh12 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Rdh12 is located on chromosome 12 of mice. SgRNA and ssDNA were designed using Nuclease Technology; Rdh12 conditional knockout mice were obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
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