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hOSMR
製品ID :
C001841
系統:
C57BL/6NCya
状況:
説明:
The oncostatin M receptor (OSMR) gene encodes the OSMRβ protein subunit, which is widely expressed in the skin (in keratinocytes), liver (in hepatocytes), and various immune cells. This protein subunit forms heterodimeric complexes with the signal transduction subunit gp130 (or IL-31Rα), serving as functional receptors for two key inflammatory cytokines: oncostatin M (OSM) and interleukin-31 (IL-31), respectively. Upon binding of these cytokines to their receptors, the JAK/STAT signaling pathway is primarily activated, thereby regulating multiple critical biological processes, including inflammatory responses, immune responses, and tissue regeneration. Dysregulation of the OSMR signaling pathway is closely linked to the pathophysiological processes of various diseases. In dermatology, mutations in the OSMR gene are the direct cause of primary localized cutaneous amyloidosis (PLCA), a rare hereditary disorder [1]. Meanwhile, excessive activation of this pathway (particularly the IL-31 axis) acts as a core driver of pruritus and inflammation in chronic inflammatory skin diseases such as atopic dermatitis [2]. In oncology, OSMR-based therapies hold potential for treating various cancers, including cervical squamous cell carcinoma and lung adenocarcinoma [3-4]. Given its central role in inflammation-driven processes and the tumor microenvironment, the OSMR signaling pathway has emerged as a key target for drug development.
The hOSMR mouse is a humanized model constructed by replacing the coding sequences of exon 2 and partial intron 2 sequence of the murine Osmr gene with the Kozak-OSMR chimeric CDS-3'UTR of mouse Osmr-WPRE-BGH pA expression cassette. This model is applicable to mechanistic research on inflammatory diseases (e.g., rheumatoid arthritis, atopic dermatitis), cancers (cervical squamous cell carcinoma, lung adenocarcinoma, pancreatic cancer), cardiovascular diseases (e.g., atherosclerosis), liver diseases (e.g., fibrosis), and hematopoietic and bone marrow-related disorders. It also supports the screening, development, and safety evaluation of OSMR-targeted drugs.
The oncostatin M receptor (OSMR) gene encodes the OSMRβ protein subunit, which is widely expressed in the skin (in keratinocytes), liver (in hepatocytes), and various immune cells. This protein subunit forms heterodimeric complexes with the signal transduction subunit gp130 (or IL-31Rα), serving as functional receptors for two key inflammatory cytokines: oncostatin M (OSM) and interleukin-31 (IL-31), respectively. Upon binding of these cytokines to their receptors, the JAK/STAT signaling pathway is primarily activated, thereby regulating multiple critical biological processes, including inflammatory responses, immune responses, and tissue regeneration. Dysregulation of the OSMR signaling pathway is closely linked to the pathophysiological processes of various diseases. In dermatology, mutations in the OSMR gene are the direct cause of primary localized cutaneous amyloidosis (PLCA), a rare hereditary disorder [1]. Meanwhile, excessive activation of this pathway (particularly the IL-31 axis) acts as a core driver of pruritus and inflammation in chronic inflammatory skin diseases such as atopic dermatitis [2]. In oncology, OSMR-based therapies hold potential for treating various cancers, including cervical squamous cell carcinoma and lung adenocarcinoma [3-4]. Given its central role in inflammation-driven processes and the tumor microenvironment, the OSMR signaling pathway has emerged as a key target for drug development.
The hOSMR mouse is a humanized model constructed by replacing the coding sequences of exon 2 and partial intron 2 sequence of the murine Osmr gene with the Kozak-OSMR chimeric CDS-3'UTR of mouse Osmr-WPRE-BGH pA expression cassette. This model is applicable to mechanistic research on inflammatory diseases (e.g., rheumatoid arthritis, atopic dermatitis), cancers (cervical squamous cell carcinoma, lung adenocarcinoma, pancreatic cancer), cardiovascular diseases (e.g., atherosclerosis), liver diseases (e.g., fibrosis), and hematopoietic and bone marrow-related disorders. It also supports the screening, development, and safety evaluation of OSMR-targeted drugs.
B6-huOSM/hOSMR
製品ID :
C001901
系統:
C57BL/6NCya
状況:
説明:
The B6-huOSM/hOSMR mouse is a dual-gene humanized model obtained by crossing B6-huOSM mice (catalog No.: C001815) with B6-hOSMR mice (catalog No.: C001841). This model can be used for studying the pathogenesis of inflammatory diseases (such as rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease), cancers (cervical squamous cell carcinoma, lung adenocarcinoma, and pancreatic cancer), pulmonary and skin diseases (such as asthma and psoriasis), cardiovascular diseases (such as atherosclerosis), liver diseases (such as fibrosis), and hematopoietic system and bone marrow-related diseases, as well as for the development of OSM/OSMR-targeted drugs.
The B6-huOSM/hOSMR mouse is a dual-gene humanized model obtained by crossing B6-huOSM mice (catalog No.: C001815) with B6-hOSMR mice (catalog No.: C001841). This model can be used for studying the pathogenesis of inflammatory diseases (such as rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease), cancers (cervical squamous cell carcinoma, lung adenocarcinoma, and pancreatic cancer), pulmonary and skin diseases (such as asthma and psoriasis), cardiovascular diseases (such as atherosclerosis), liver diseases (such as fibrosis), and hematopoietic system and bone marrow-related diseases, as well as for the development of OSM/OSMR-targeted drugs.
huTL1A/hOSMR
製品ID :
C002073
系統:
C57BL/6N;6JCya
状況:
説明:
The huTL1A/hOSMR mouse is a dual-gene humanized model obtained by crossing the huTL1A(TNFSF15) mouse (Catalog No.: C001603) with the hOSMR mouse (Catalog No.: C001841). The huTL1A/hOSMR mouse is a dual-target humanized model that integrates immune-inflammatory regulation with inflammation and fibrosis regulation. Co-expressing humanized TNFSF15 and OSMR genes, this model can be utilized for the screening, pharmacodynamic evaluation, safety assessment, and synergistic mechanism studies of dual-target therapeutics targeting TL1A and OSMR. It serves as an ideal research platform for investigating the pathogenesis of inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and other immune-inflammatory diseases.
The huTL1A/hOSMR mouse is a dual-gene humanized model obtained by crossing the huTL1A(TNFSF15) mouse (Catalog No.: C001603) with the hOSMR mouse (Catalog No.: C001841). The huTL1A/hOSMR mouse is a dual-target humanized model that integrates immune-inflammatory regulation with inflammation and fibrosis regulation. Co-expressing humanized TNFSF15 and OSMR genes, this model can be utilized for the screening, pharmacodynamic evaluation, safety assessment, and synergistic mechanism studies of dual-target therapeutics targeting TL1A and OSMR. It serves as an ideal research platform for investigating the pathogenesis of inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and other immune-inflammatory diseases.
huIL4/huIL4R/hOSMR
製品ID :
C002072
系統:
C57BL/6NCya
状況:
説明:
The huIL4/huIL4R/hOSMR mouse is a triple-gene humanized model obtained by crossing the huIL4/huIL4RA mouse (Catalog No.: C001834) with the hOSMR mouse (Catalog No.: C001841). The huIL4/huIL4R/hOSMR mouse is a multi-target humanized model that integrates Th2-type immune-inflammatory regulation with tissue inflammatory response regulation. Co-expressing humanized IL4, IL4R, and OSMR genes, this model can be utilized for the screening, pharmacodynamic evaluation, safety assessment, and mechanism of action studies of multi-target therapeutics targeting IL4, IL4R, and OSMR. It serves as an ideal preclinical research platform for developing innovative therapies for atopic dermatitis (AD) and other Th2-mediated inflammatory diseases.
The huIL4/huIL4R/hOSMR mouse is a triple-gene humanized model obtained by crossing the huIL4/huIL4RA mouse (Catalog No.: C001834) with the hOSMR mouse (Catalog No.: C001841). The huIL4/huIL4R/hOSMR mouse is a multi-target humanized model that integrates Th2-type immune-inflammatory regulation with tissue inflammatory response regulation. Co-expressing humanized IL4, IL4R, and OSMR genes, this model can be utilized for the screening, pharmacodynamic evaluation, safety assessment, and mechanism of action studies of multi-target therapeutics targeting IL4, IL4R, and OSMR. It serves as an ideal preclinical research platform for developing innovative therapies for atopic dermatitis (AD) and other Th2-mediated inflammatory diseases.
Cep295-KO
製品ID :
S-KO-09180
系統:
C57BL/6NCya
状況:
説明:
Cep295 is located on chromosome 9 of mice. Nuclease Technology was used to design sgRNA; Cep295 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Cep295 is located on chromosome 9 of mice. Nuclease Technology was used to design sgRNA; Cep295 knockout mice were obtained by applying high-throughput electroporation of fertilized eggs. After sexual maturity, sperm were collected for cryopreservation.
Or5an1-flox
製品ID :
S-CKO-09180
系統:
C57BL/6JCya
状況:
説明:
Or5an1 is located on chromosome 19 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Or5an1 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
Or5an1 is located on chromosome 19 of mice. SgRNA and ssDNA will be designed using Nuclease Technology; Or5an1 conditional knockout mice will be obtained by high-throughput electroporation of fertilized eggs. After sexual maturity, sperm will be collected for cryopreservation.
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