B6-Il2rg KO Mouse

The interleukin-2 receptor subunit gamma (IL2Rg or CD132) gene encodes a protein that is an important signaling component of many interleukin receptors and is a common receptor subunit for several important immune factors, including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. IL2Rg is a glycoprotein expressed on the surface of most lymphocytes. In mammals, the IL2Rg gene is located on the X chromosome, and mutations in IL2Rg in humans can lead to X-linked severe combined immunodeficiency (X-SCID).

B6-Il2rg KO mice were obtained by knocking out the expression of the Il2rg gene in C57BL/6JCya mice, which are severely deficient in B and T cells in peripheral blood and bone marrow and partially deficient in the spleen, while the mice show a severe immunodeficient phenotype with almost complete absence of NK cells in peripheral blood, spleen, and bone marrow. This strain can be used for research in the fields of oncology, immunology, infectious disease, and stem cell biology.