huIL4(BALB/c) Mouse
製品名
huIL4(BALB/c) Mouse
製品ID
C001780
系統名
BALB/cAnCya-Il4em1(hIL4)/Cya
背景情報
BALB/cAnCya
状況
このマウス系統を論文で使用する場合は、「huIL4(BALB/c) Mouse（カタログ番号C001780）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子名
遺伝子別名
BSF1, IL-4, BCGF1, BSF-1, BCGF-1
NCBI ID
染色体
Chr 5
MGI ID
さらに
系統詳細
Interleukin-4 (IL-4) and its receptor, IL-4R, are pivotal regulators of immune responses and inflammation. The IL4 gene encodes the IL-4 cytokine, a multifunctional protein predominantly secreted by Th2 cells, mast cells, and eosinophils, while the IL4R gene encodes the IL-4 receptor, which is expressed on a variety of immune cells, including B cells, T cells, macrophages, and endothelial cells. IL-4 binds to IL-4R, which exists in two distinct forms: Type I (comprising IL-4Rα and the common γ-chain) and Type II (comprising IL-4Rα and IL-13Rα1) [1]. This interaction activates the JAK-STAT signaling pathway, driving Th2 cell differentiation, B cell class switching to IgE, and anti-inflammatory responses. The IL-4/IL-4R signaling axis is critically implicated in allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis, as well as in parasitic infections and certain cancers [2-5]. Dysregulation of this pathway underlies various pathological conditions, positioning IL-4 as a promising therapeutic target.
The huIL4(BALB/c) mouse is a humanized model constructed via gene-editing technology, where the sequences from the start codon to the stop codon of the endogenous mouse Il4 gene were replaced with those of the human IL4 gene. This model serves as a valuable tool for researching allergic diseases (such as asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. Additionally, it provides a robust preclinical research platform for evaluating the efficacy and mechanisms of therapeutic drugs targeting the IL-4 pathway.
参考文献
Gandhi NA, Bennett BL, Graham NM, Pirozzi G, Stahl N, Yancopoulos GD. Targeting key proximal drivers of type 2 inflammation in disease. Nat Rev Drug Discov. 2016 Jan;15(1):35-50.
Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS. Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. Cell. 2017 Sep 21;171(1):217-228.e13.
Bankaitis KV, Fingleton B. Targeting IL4/IL4R for the treatment of epithelial cancer metastasis. Clin Exp Metastasis. 2015 Dec;32(8):847-56.
Davoodi P, Mahesh PA, Holla AD, Ramachandra NB. A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4Rα) & Toll-like receptor 4 (TLR4) genes with asthma in Indian adults. Indian J Med Res. 2015 Dec;142(6):675-80.
Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, Jia G, Ohri CM, Doran E, Vannella KM, Butler CA, Hargadon B, Sciurba JC, Gieseck RL, Thompson RW, White S, Abbas AR, Jackman J, Wu LC, Egen JG, Heaney LG, Ramalingam TR, Arron JR, Wynn TA, Bradding P. TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma. Sci Transl Med. 2015 Aug 19;7(301):301ra129.
系統作製戦略
The sequences from the start codon to the stop codon of the endogenous mouse Il4 gene were replaced with the sequences from the start codon to the stop codon of the human IL4 gene.
Figure 1. Gene editing strategy of huIL4(BALB/c) mice.
適用分野
Investigation of immune regulation and Th2 responses, allergic diseases, parasitic infections, and tumor immunology;
Preclinical development, screening, and efficacy evaluation of IL4-targeted therapeutic agents;
Studies on inflammation and autoimmune diseases.
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