hTFRC/huCD98HC Mouse
製品名
hTFRC/huCD98HC Mouse
製品ID
C001971
系統名
C57BL/6NCya-Tfrctm1(hTFRC)Slc3a2tm1(hSLC3A2)/Cya
背景情報
C57BL/6NCya
状況
このマウス系統を論文で使用する場合は、「hTFRC/huCD98HC Mouse（カタログ番号C001971）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子別名
4F2, CD98, MDU1, 4F2HC, 4T2HC, NACAE, CD98HC, T9, TR, TFR, p90, CD71, TFR1, TRFR, IMD46
染色体
Chr 11, Chr 3
さらに
系統詳細
The hTFRC/huCD98HC mouse is a dual-gene humanized model obtained by mating hTFRC mice (catalog No.: C001584) with huCD98HC (SLC3A2) mice (catalog No.: C001857). This model can be used for research and evaluation of drug delivery across the blood-brain barrier (BBB), related research on cancer, amino acid transport and metabolic intervention, immune regulation and autoimmunity, as well as the development of TFRC/SLC3A2-targeted drugs.
系統作製戦略
The hTFRC/huCD98HC mouse is a dual-gene humanized model obtained by crossing the hTFRC mouse (catalog No.: C001584) with the huCD98HC(SLC3A2) mouse (catalog No.: C001857).
Figure 1a. Diagram of the gene editing strategy for the generation of hTFRC mice.
*TFRC chimeric cDNA: Mouse cytoplasmic and helical-Human extracellular.
Figure 1b. Diagram of the gene editing strategy for the generation of hTFRC mice. TurboKnockout targeting technology was used to replace part of exon 2 of the mouse Tfrc gene with a human TFRC chimeric cDNA WPRE-BGH pA cassette. Gene-editing techniques were employed to knock out exons 10-13 of the mouse Tfrc gene.
Figure 2. Gene editing strategy of huCD98HC(SLC3A2) mice. The mouse Slc3a2 endogenous extracellular domain was replaced with the human SLC3A2 extracellular domain. The murine cytoplasmic domain and transmembrane domain were preserved.
適用分野
Screening, development, and preclinical evaluation of TFRC/CD98HC(SLC3A2)-targeted drugs;
Research on drug delivery across the blood-brain barrier (BBB);
Research on the pathological mechanisms and treatment methods of various cancers;
Research on amino acid transport mechanisms and metabolic diseases;
Research on immune regulation and autoimmunity.
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