huIL18 Mouse
製品名
huIL18 Mouse
製品ID
C001988
系統名
C57BL/6NCya-Il18tm1(hIL18)/Cya
背景情報
C57BL/6NCya
状況
このマウス系統を論文で使用する場合は、「huIL18 Mouse（カタログ番号C001988）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子名
遺伝子別名
IGIF, IL-18, IL-1g, IL1F4
NCBI ID
染色体
Chr 11
MGI ID
さらに
系統詳細
Interleukin-18 (IL18) is a pro-inflammatory cytokine primarily secreted by macrophages, dendritic cells, and keratinocytes. It is a member of the IL-1 superfamily and plays an important regulatory role in both innate and adaptive immune responses [1]. IL18 binds to the IL18 receptor (IL18R) and, in synergy with IL12, induces Th1 cells to produce interferon-γ (IFN-γ), promoting the activation and proliferation of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells, while also participating in the regulation of inflammasome-mediated inflammatory responses [2-3]. The IL18 gene is located on human chromosome 11 and is closely associated with the development of various autoimmune diseases, infectious diseases, and cancers. It has emerged as an important target for tumor immunotherapy, infectious vaccine development, and drug research for autoimmune diseases [4-5].
The huIL18 mouse is a humanized model constructed by gene-editing technology, in which the sequence from the start codon to the stop codon of the mouse endogenous Il18 gene is replaced with the corresponding sequence of the human IL18 gene. This model is suitable for evaluating the efficacy and safety of IL18-targeted antibodies and CAR-cell therapies, as well as for preclinical studies in tumor immunity, infectious disease vaccines, autoimmune disorders, and metabolic and cardiovascular diseases.
参考文献
Okamura H, Tsutsi H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells[J]. Nature, 1995, 378(6552): 88-91.
Dinarello C A. IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family[J]. J Allergy Clin Immunol, 1999, 103(1): 11-24.
Gu Y, Kuida K, Tsutsui H, et al. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme[J]. Science, 1997, 275(5297): 206-209.
Robertson M J, Mier J W, Logan T, et al. Clinical and biological effects of recombinant human interleukin-18 administered by intravenous infusion to patients with advanced cancer[J]. Clin Cancer Res, 2006, 12(14): 4268-4277.
Torigoe K, Ushio S, Okura T, et al. Purification and characterization of the human interleukin-18 receptor[J]. J Biol Chem, 1997, 272(41): 25737-25742.
系統作製戦略
The sequences from the start codon to the stop codon of the endogenous mouse Il18 gene were replaced with the sequences from the start codon to the stop codon of the human IL18 gene.
Figure 1. Gene editing strategy of huIL18 mice.
適用分野
Research on tumor immunotherapy;
Development and evaluation of infectious disease vaccines;
Research on the mechanisms of autoimmune diseases and drug screening;
Research on metabolic and cardiovascular diseases;
Research on inflammasomes and innate immune signaling pathways;
Preclinical evaluation of IL18-targeted drugs.
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