huIL4/huIL4R/huTSLP/hTSLPR Mouse
製品名
huIL4/huIL4R/huTSLP/hTSLPR Mouse
製品ID
C001996
系統名
C57BL/6NCya-Il4em1(hIL4)Il4raem1(hIL4R)Tslpem1(hTSLP)Crlf2tm1(hCRLF2)/Cya
背景情報
C57BL/6NCya
状況
このマウス系統を論文で使用する場合は、「huIL4/huIL4R/huTSLP/hTSLPR Mouse（カタログ番号C001996）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子別名
BSF1, IL-4, BCGF1, BSF-1, BCGF-1, CD124, IL4RA, IL-4RA, CRL2, TSLPR, CRLF2Y
染色体
Chr 5, Chr 16, Chr X, Chr 5
MGI ID
さらに
系統詳細
The huIL4/huIL4R/huTSLP/hTSLPR mice are a quadruple-gene humanized model obtained by mating huIL4/huIL4R mice (catalog number: C001834), huTSLP mice (catalog number: C001809), and hTSLPR mice (catalog number: C001942). This model is a valuable tool for studying allergic diseases (such as asthma and atopic dermatitis), Th2 immune responses, parasitic infections, tumor immunology, and chronic inflammation. In addition, this model also provides a powerful preclinical research platform for evaluating the efficacy and mechanism of therapeutic drugs targeting IL4/IL4R/TSLP/TSLPR.
系統作製戦略
The huIL4/huIL4R/huTSLP/hTSLPR mice are a quadruple-gene humanized model obtained by mating huIL4/huIL4R mice (catalog number: C001834), huTSLP mice (catalog number: C001809), and hTSLPR mice (catalog number: C001942).
Figure 1. Gene editing strategy of huIL4 mice. The sequences from the ATG start codon to the TAG stop codon of the endogenous mouse Il4 gene were replaced with the sequences from the ATG start codon to the TGA stop codon of the human IL4 gene.
Figure 2. Gene editing strategy of huIL4R mice. The extracellular domain of the mouse Il4ra was replaced with the corresponding human IL4R extracellular domain, while retaining the murine signal peptide.
Figure 3. Gene editing strategy of huTSLP mice. The mouse Tslp endogenous domain was replaced with the human TSLP domain. The murine signal peptide was preserved.
Figure 4. Gene editing strategy of hTSLPR mice. Part of exon 1 to intron 7 of Mouse Crlf2 was replaced with Human CRLF2 CDS-Mouse Crlf2 CDS cassette.
適用分野
Screening, development and safety evaluation of IL4/IL4R/TSLP/TSLPR-targeted drugs;
Research on the pathogenic mechanisms and related treatment methods of inflammatory and allergic diseases, such as asthma and allergic rhinitis;
Research on immune regulation, parasitic infections, and tumor immunity.
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