huCNR1(2) Mouse
製品名
huCNR1(2) Mouse
製品ID
C002023
系統名
C57BL/6NCya-Cnr1tm2(hCNR1)/Cya
背景情報
C57BL/6NCya
状況
このマウス系統を論文で使用する場合は、「huCNR1(2) Mouse（カタログ番号C002023）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子名
遺伝子別名
CB1, CNR, CB-R, CB1A, CB1R, CANN6, CB1K5
NCBI ID
染色体
Chr 6
MGI ID
さらに
系統詳細
Cannabinoid receptor 1 (CNR1) is a member of the G protein-coupled receptor (GPCR) superfamily, predominantly expressed in the central nervous system regions, including the cerebral cortex, hippocampus, basal ganglia, and cerebellum [1]. CNR1 binds to endocannabinoids and mediates retrograde trans-synaptic signaling, modulating the release of neurotransmitters such as GABA and glutamate, thereby regulating diverse physiological processes including appetite, energy metabolism, mood, cognition, and addiction [2]. Studies have shown that CNR1 dysfunction is closely associated with obesity, type 2 diabetes (T2D), schizophrenia, and substance dependence, establishing CNR1 as an important drug target for metabolic and neuropsychiatric diseases [3].
The huCNR1(2) mouse is a humanized model generated via gene editing. The sequences from the start codon to the 3'UTR of the endogenous mouse Cnr1 gene were replaced with the sequences from the start codon to the 3'UTR of the human CNR1 gene. This model is suitable for studying the mechanisms of metabolic and neuropsychiatric disorders, as well as for the screening, development, and preclinical in vivo evaluation of CNR1-targeted candidate drugs.
参考文献
Mackie K. Cannabinoid receptors: where they are and what they do. J Neuroendocrinol. 2008 May;20 Suppl 1:10-4.
Mechoulam R, Parker LA. The endocannabinoid system and the brain. Annu Rev Psychol. 2013;64:21-47.
Piazza PV, Cota D, Marsicano G. The CB1 receptor as the cornerstone of exostasis. Neuron. 2017 Mar 22;93(6):1252-1274.
系統作製戦略
The sequences from the start codon to the 3'UTR of the endogenous mouse Cnr1 gene were replaced with the sequences from the start codon to the 3'UTR of the human CNR1 gene.
Figure 1. Gene editing strategy for huCNR1(2) mice.
適用分野
Research on metabolic diseases, such as obesity and type 2 diabetes (T2D);
Research on the pathogenesis of neuropsychiatric diseases (anxiety, addiction, cognitive impairment);
Screening, development, and preclinical evaluation of CNR1-targeted drugs.
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