huINHBE/huCIDEB(2) Mouse
製品名
huINHBE/huCIDEB(2) Mouse
製品ID
C002025
系統名
C57BL/6N;6JCya-Cidebem1Gt(ROSA)26Sortm1(hCIDEB)Inhbetm1(hINHBE)/Cya
背景情報
C57BL/6N;6JCya
状況
このマウス系統を論文で使用する場合は、「huINHBE/huCIDEB(2) Mouse（カタログ番号C002025）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子別名
--
染色体
Chr 14, Chr 12
MGI ID
さらに
系統詳細
The huINHBE/huCIDEB(2) mice are a double-gene humanized model obtained by mating huINHBE mice (Catalog Number: C001533) with huCIDEB(2) mice (Catalog Number: C001990). This model is applicable to the study of pathogenesis of various liver diseases, such as Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Dysfunction-Associated Steatohepatitis (MASH), cirrhosis, and viral hepatitis (HCV, HBV), as well as the research on obesity and metabolic diseases associated with improper fat distribution and storage. It can also be used for the screening, development, and preclinical evaluation of INHBE/CIDEB-targeted therapeutics.
系統作製戦略
The huINHBE/huCIDEB(2) mice are a double-gene humanized model obtained by mating huINHBE mice (Catalog Number: C001533) with huCIDEB(2) mice (Catalog Number: C001990).
Figure 1. Gene editing strategy of huINHBE mice. The sequences from the ATG start codon to 3'UTR of mouse Inhbe were replaced with the sequences from the ATG start codon to 3'UTR of human INHBE.
Figure 2. Gene editing strategy for huCIDEB(2) mice. The sequence from upstream of exon 1 of the human CIDEB gene to downstream of exon 5 of the human CIDEB gene was cloned into intron 1 of ROSA26 in reverse orientation. The Cideb gene contains five exons, with the ATG start codon located in exon 1 and the TAA stop codon located in exon 5. The coding region of exon 2 was selected as the target site.
適用分野
Screening, development, and preclinical evaluation of INHBE/CIDEB-targeted drugs;
Research on the pathological mechanisms and treatment methods of various liver diseases, such as Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Metabolic Dysfunction-Associated Steatohepatitis (MASH), cirrhosis, and viral hepatitis (HCV, HBV);
Research on metabolic syndrome, obesity, and metabolic diseases related to improper fat distribution and storage.
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