hCDH17 Mouse
製品名
hCDH17 Mouse
製品ID
C002045
系統名
C57BL/6NCya-Cdh17tm1(hCDH17)/Cya
背景情報
C57BL/6NCya
状況
このマウス系統を論文で使用する場合は、「hCDH17 Mouse（カタログ番号C002045）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子名
遺伝子別名
HPT1, CDH16, HPT-1
NCBI ID
染色体
Chr 8
MGI ID
さらに
系統詳細
CDH17 (Cadherin 17), a member of the cadherin superfamily encoded by the CDH17 gene, is also known as liver-intestine cadherin (LI-cadherin). It is primarily expressed in the epithelial cells of the digestive tract, such as the small intestine and colon, and plays a crucial role in cell adhesion, maintenance of the epithelial barrier, and intestinal tissue homeostasis [1-2]. Studies have shown that CDH17 is abnormally overexpressed in various gastrointestinal tumors, including gastric, colorectal, pancreatic, and hepatocellular carcinomas. Its expression is closely associated with tumor proliferation, invasion, metastasis, and poor prognosis, making it a promising potential therapeutic target [2-4]. Currently, research involving CDH17-targeting monoclonal antibodies, antibody-drug conjugates (ADCs), and CAR-T/CAR-NK cell therapies is underway to explore their potential in the targeted treatment of gastrointestinal cancers [3-5].
The hCDH17 mouse is a humanized model generated via gene editing. In this model, the region from aa.28 in exon 3 to partial intron 3 of the mouse Cdh17 was replaced with Mature Chimeric CDH17 CDS-3’UTR of the mouse Cdh17-WPRE-BGH pA cassette. The murine signal peptide was preserved. This model is suitable for evaluating the in vivo efficacy and safety of CDH17-targeting monoclonal antibodies, ADCs, and CAR-T/CAR-NK cell therapies. It is also applicable for research into the mechanisms of gastrointestinal tumor development, the tumor immune microenvironment, and combination therapeutic strategies.
参考文献
Berndorff D, Gessner R, Kreft B, et al. Liver-intestine cadherin: molecular cloning and characterization of a novel Ca(2+)-dependent cell adhesion molecule expressed in liver and intestine. J Cell Biol. 1994, 125(6):1353-1369.
Wang J, Yu JC, Kang WM, et al. The predictive effect of cadherin-17 on lymph node micrometastasis in pN0 gastric cancer. Ann Surg Oncol. 2012, 19(5):1529-1534.
Bartolomé RA, Barderas R, Torres S, et al. Cadherin-17 interacts with α2β1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis. Oncogene. 2014, 33(13):1658-1669.
Su MC, Yuan RH, Lin CY, et al. Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system. Mod Pathol. 2008, 21(11):1379-1386.
Senoo A, Hagiwara S, Wang L, et al. Development of anti-CDH17 antibody-drug conjugate for gastrointestinal cancers. Mol Cancer Ther. 2021, 20(12):2320-2331.
系統作製戦略
The region from aa.28 in exon 3 to partial intron 3 of the mouse Cdh17 was replaced with Mature Chimeric CDH17 CDS-3’UTR of the mouse Cdh17-WPRE-BGH pA cassette. The murine signal peptide was preserved.
*Mature Chimeric CDH17 CDS: Human CDH17 Extracellular domain-Mouse Cdh17 Transmembrane and Cytoplasmic domain.
Figure 1. Gene targeting strategy for hCDH17 mice.
適用分野
Investigation into the mechanisms of gastrointestinal tumorigenesis and progression;
Development and safety evaluation of CDH17-targeted therapeutics;
Research on tumor immunotherapy and combination treatment strategies.
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