hITGA4 Mouse
製品名
hITGA4 Mouse
製品ID
C002091
系統名
C57BL/6NCya-Itga4em2(hITGA4)/Cya
背景情報
C57BL/6NCya
状況
このマウス系統を論文で使用する場合は、「hITGA4 Mouse（カタログ番号C002091）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子名
遺伝子別名
IA4, CD49D
NCBI ID
染色体
Chr 2
MGI ID
さらに
系統詳細
The ITGA4 gene encodes the integrin α4 subunit, which associates with the integrin β7 subunit (ITGB7) to form the heterodimeric transmembrane protein α4β7, an important member of the integrin family [1,2]. The α4β7 integrin is expressed in a variety of cells and tissues and is highly expressed in immune tissues such as lymph nodes, bone marrow, spleen, and blood, as well as in multiple immune cell types including T lymphocytes, B lymphocytes, monocytes, granulocytes, and natural killer cells [3]. Its primary functions are to mediate cell adhesion and migration, thereby regulating the tissue homing of immune cells and inflammatory responses. By binding to vascular cell adhesion molecule-1 (VCAM-1) and mucosal addressin cell adhesion molecule-1 (MAdCAM-1), α4β7 promotes the migration of lymphocytes to inflamed tissues and gut-associated lymphoid tissues [1,2,4]. Studies have shown that the ITGA4 gene is closely linked to the pathogenesis and progression of multiple diseases, including autoimmune disorders such as inflammatory bowel disease (IBD), Crohn’s disease, ulcerative colitis, and multiple sclerosis (MS) [1,2,5]. Furthermore, high expression of ITGA4 in gastric cancer is associated with poor prognosis, cell proliferation and migration, as well as immune infiltration; its downregulation inhibits migration and promotes apoptosis [3]. Given the critical role of α4β7 integrin in inflammation and immune responses, targeting α4β7 has become an important research direction for the treatment of inflammatory and autoimmune diseases.
The hITGA4 mouse is a humanized model generated by gene-editing technology. The coding sequences of exon 2 plus partial intron 2 of mouse Itga4 were replaced with Chimeric ITGA4 CDS-WPRE-BGH pA cassette. The murine signal peptide was retained. hITGA4 mice can be used to investigate the pathological mechanisms and therapeutic strategies of inflammatory and autoimmune diseases, as well as for the screening, development, and preclinical efficacy and safety evaluation of ITGA4-targeted drugs.
参考文献
De Matos MD, Guimenes BD, Pavani GK, Fernandes GG, Montes GC, Fontes-Dantas FL. ITGA4 genetic variants as a predictor of therapeutic responsivity to autoimmune diseases. Front Pharmacol. 2026;16:1745315.
GeneCards. ITGA4 Gene - GeneCards. Accessed July 28, 2026.
Zhang J, Wang G, Liu J, Tang F, Wang S, Li Y. ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation. Front Oncol. 2025;15:1513622.
Kelly AJ, Long A. Targeting T-cell integrins in autoimmune and inflammatory diseases. Clin Exp Immunol. 2024;215(1):15-26.
Abdel-Magid AF. The Potential of the Alpha4 Beta7 Integrin Inhibitors as Treatment for Inflammatory Bowel Diseases and Related Disorders. ACS Med Chem Lett. 2025;16(11):2185-2187.
系統作製戦略
The coding sequences of exon 2 plus partial intron 2 of mouse Itga4 were replaced with Chimeric ITGA4 CDS-WPRE-BGH pA cassette. The murine signal peptide was retained.
Figure 1. Gene editing strategy of hITGA4 mice.
適用分野
ITGA4-targeted drug screening, development, and preclinical evaluation;
Research on the pathological mechanisms and therapeutic approaches of inflammatory and autoimmune diseases such as inflammatory bowel disease (IBD) and multiple sclerosis (MS).
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