huTSLP/hTSLPR/huIL7R Mouse
製品名
huTSLP/hTSLPR/huIL7R Mouse
製品ID
C002094
系統名
C57BL/6Cya-Tslpem1(hTSLP)Crlf2tm1(hCRLF2)Il7rem1(hIL7R)/Cya
背景情報
C57BL/6Cya
状況
このマウス系統を論文で使用する場合は、「huTSLP/hTSLPR/huIL7R Mouse（カタログ番号C002094）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子別名
ILRA, CD127, IL7RA, CDW127, IMD104, sIL-7R, lnc-IL7R, IL7Ralpha, IL-7Ralpha, IL-7R-alpha, CRL2, TSLPR, CRLF2Y
染色体
Chr 5, Chr X, Chr 5
MGI ID
さらに
系統詳細
TSLP (thymic stromal lymphopoietin) is a cytokine involved in the initiation of immune responses and the regulation of allergic inflammation [1-2]; TSLPR (thymic stromal lymphopoietin receptor), encoded by the CRLF2 gene, forms a TSLP receptor complex with IL-7Rα (interleukin-7 receptor alpha), which can bind the ligand TSLP [3]; IL7R encodes IL-7Rα, which is involved in lymphocyte survival, proliferation, differentiation, and the maintenance of immune homeostasis [4]. Based on this ligand–receptor relationship, the combined design of humanized TSLP, TSLPR, and IL7R can be utilized to study immune regulation associated with TSLP–TSLPR/IL7R from the perspective of the ligand and receptor complex components.
The huTSLP/hTSLPR/huIL7R mouse is a triple-gene humanized model obtained by crossing the huTSLP mouse (Catalog No.: C001809), the hTSLPR mouse (Catalog No.: C001942), and the huIL7R mouse (Catalog No.: C001633). The huTSLP/hTSLPR/huIL7R mouse incorporates a combined design involving humanized TSLP, TSLPR, and IL7R and can be utilized for studies of immune regulation associated with the TSLP–TSLPR/IL-7R receptor complex, including JAK/STAT and PI3K/AKT/mTOR signaling regulation; studies of inflammatory and allergic diseases including asthma and allergic rhinitis; and the screening, development, pharmacodynamic evaluation, and safety assessment of related targeted therapeutics.
参考文献
Parnes JR, Molfino NA, Colice G, Martin U, Corren J, Menzies-Gow A. Targeting TSLP in Asthma. J Asthma Allergy. 2022 Jun 3;15:749-765.
Nakajima S, Kabata H, Kabashima K, Asano K. Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses. Allergol Int. 2020 Apr;69(2):197-203.
Tasian SK, Loh ML. Understanding the biology of CRLF2-overexpressing acute lymphoblastic leukemia. Crit Rev Oncog. 2011;16(1-2):13-24.
Barata JT, Durum SK, Seddon B. Flip the coin: IL-7 and IL-7R in health and disease. Nat Immunol. 2019 Dec;20(12):1584-1593.
系統作製戦略
The huTSLP/hTSLPR/huIL7R mouse is a triple-gene humanized model obtained by crossing the huTSLP mouse (Catalog No.: C001809), the hTSLPR mouse (Catalog No.: C001942), and the huIL7R mouse (Catalog No.: C001633).
Figure 1. Gene editing strategy of huTSLP mice. The mouse Tslp endogenous domain was replaced with the human TSLP domain. The murine signal peptide was preserved.
Figure 2. Gene editing strategy of hTSLPR mice. Part of exon 1 to intron 7 of Mouse Crlf2 was replaced with Human CRLF2 CDS-Mouse Crlf2 CDS cassette.
Figure 3. Gene editing strategy of huIL7R mice. The mouse Il7r endogenous extracellular domain was replaced with the human IL7R extracellular domain. The murine IL7R signal peptide and cytoplasmic region was preserved.
適用分野
Studies of immune regulatory mechanisms associated with TSLP–TSLPR/IL-7R, including JAK/STAT and PI3K/AKT/mTOR signaling regulation;
Studies of inflammatory and allergic diseases including asthma and allergic rhinitis;
Screening, development, pharmacodynamic evaluation, and safety assessment of therapeutics targeting TSLP, TSLPR, and IL7R.
お問い合わせ
カスタムの動物モデルに関するご相談は、下記のフォームにご記入いただき、ご連絡いただくか見積もりをご依頼ください。
Cyagenはお客様のプライバシーを大変重視しています。当社の最新の製品や情報をお届けしたいと思っています。お客様の設定をご確認ください。
これらの配信はいつでも解除できます。配信停止方法およびデータ保護の詳細は プライバシーポリシー をご確認ください。
以下のボタンをクリックすることで、このフォームにご入力いただいた個人情報をCyagenが保存・処理し、ご要望のコンテンツを提供することに同意されたことになります。