huIL18/huIL18R1/huIL18RAP Mouse
製品名
huIL18/huIL18R1/huIL18RAP Mouse
製品ID
C002102
系統名
C57BL/6Cya-Il18tm1(hIL18)Il18r1tm1(hIL18R1)Il18raptm1(hIL18RAP)/Cya
背景情報
C57BL/6Cya
状況
このマウス系統を論文で使用する場合は、「huIL18/huIL18R1/huIL18RAP Mouse（カタログ番号C002102）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
遺伝子別名
IGIF, IL-18, IL-1g, IL1F4, ACPL, CD218b, IL-1R7, IL18RB, CDw218b, IL-1R-7, IL-18RAcP, IL-1RAcPL, IL-18Rbeta, IL-18R-beta, CD218a, IL18RA, IL1RRP, CDw218a, IL-1Rrp, IL-18Ralpha, IL18Ralpha2, IL-18R-alpha
染色体
Chr 11, Chr 2, Chr 2
MGI ID
さらに
系統詳細
The huIL18/huIL18R1/huIL18RAP mouse is a triple-gene humanized model generated by crossing the huIL18 mouse (Catalog No.: C001988) with the huIL18R1/huIL18RAP mouse (Catalog No.: C002016). This model can be used for research on immunological mechanisms and therapeutic strategies in multiple fields, including autoimmune diseases, metabolic disorders, inflammatory conditions, and tumors, as well as to preclinical studies such as the development, screening, and efficacy evaluation of drugs targeting the IL-18/IL-18R pathway.
系統作製戦略
The huIL18/huIL18R1/huIL18RAP mouse is a triple‑gene humanized model generated by crossing the huIL18 mouse (Catalog No.: C001988) with the huIL18R1/huIL18RAP mouse (Catalog No.: C002016).
Figure 1. Gene editing strategy of huIL18 mice. The sequences from the start codon to the stop codon of the endogenous mouse Il18 gene were replaced with the sequences from the start codon to the stop codon of the human IL18 gene.
Figure 2. Gene editing strategy of huIL18R1/huIL18RAP mice. The sequence from exon 1 of the mouse Il18r1 gene to the downstream of exon 13 of the Il18rap gene was replaced with the sequence from exon 1 of the human IL18R1 gene to the downstream of exon 10 of the IL18RAP gene. Since the replaced human genomic fragment contains the SDR42E1P5 pseudogene and MIR4772 microRNA gene, these human genomic elements were also introduced into the mouse genome as part of the humanized region.
適用分野
Research on the immune mechanisms of autoimmune diseases, metabolic diseases, inflammation, and tumors;
Pre-clinical research such as the research and development, screening, and efficacy evaluation of IL-18/IL-18R targeted drugs.
お問い合わせ
カスタムの動物モデルに関するご相談は、下記のフォームにご記入いただき、ご連絡いただくか見積もりをご依頼ください。
Cyagenはお客様のプライバシーを大変重視しています。当社の最新の製品や情報をお届けしたいと思っています。お客様の設定をご確認ください。
これらの配信はいつでも解除できます。配信停止方法およびデータ保護の詳細は プライバシーポリシー をご確認ください。
以下のボタンをクリックすることで、このフォームにご入力いただいた個人情報をCyagenが保存・処理し、ご要望のコンテンツを提供することに同意されたことになります。