Hsd17b11-flox Mouse
一般名
Hsd17b11-flox
製品ID
S-CKO-01007
背景情報
C57BL/6JCya
系統ID
CKOCMP-114664-Hsd17b11-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Hsd17b11-flox Mouse（カタログ番号S-CKO-01007）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Hsd17b11-flox
系統ID
CKOCMP-114664-Hsd17b11-B6J-VA
遺伝子名
製品ID
S-CKO-01007
遺伝子別名
SDR2, Dhrs8, Pan1b, retSDR2
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 5
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000031251
NCBIトランスクリプトID
NM_053262
ターゲット領域
Exon 3~4
有効領域の大きさ
~2.6 kb
遺伝子研究の概要
Hsd17b11, encoding type 11 17β-hydroxysteroid dehydrogenase, catalyzes the conversion of 5α-androstan-3α,17β-diol into androsterone, suggesting its role in androgen metabolism [7]. It is also associated with fatty acid and arachidonic acid absorption and metabolism [2].
In cancer research, its high expression in CRC primary tissues was related to poor prognosis, and it promoted CRC cell proliferation and metastasis through the lnc-HSD17B11-1:1/miR-338-3p/MACC1 axis [1]. In LUAD, low expression of Hsd17b11 was associated with increased recurrence rate [2]. In pancreatic cancer, its differential expression was found, and it was significantly associated with overall survival [5]. In esophageal cancer, FTO promoted lipid droplet formation in cells by enhancing Hsd17b11 expression [6]. Also, Hsd17B11 was identified as a mediator of the selective cytotoxic effects of dehydrofalcarinol in MSL subtype triple-negative breast cancer cells [8]. In addition, phenyl-dialkynylcarbinols can be bio-oxidized by HSD17B11, leading to endoplasmic reticulum stress and apoptosis [3]. Moreover, in hepatocytes, HSD17B11 was found to be an interaction partner contributing to GCKIII-mediated regulation of liver lipid homeostasis [4].
In conclusion, Hsd17b11 is involved in androgen and lipid metabolism. Its dysregulation is associated with various cancers, affecting tumor progression, metastasis, and patient prognosis. Functional studies, especially in the context of cancer, contribute to understanding its role in disease mechanisms, potentially providing new diagnostic and therapeutic targets.
References：
1. Zhang, Wei, Wang, Bo, Wang, Quan, Jiang, Kewei, Wang, Shan. 2020. Lnc-HSD17B11-1:1 Functions as a Competing Endogenous RNA to Promote Colorectal Cancer Progression by Sponging miR-338-3p to Upregulate MACC1. In Frontiers in genetics, 11, 628. doi:10.3389/fgene.2020.00628. https://pubmed.ncbi.nlm.nih.gov/32595704/
2. Wei, Chunhui, Li, Lixia, Qiao, Youping, Huang, Dan, Wu, Dong. . Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor microenvironment and predict overall survival of lung adenocarcinoma patients. In Medicine, 103, e38322. doi:10.1097/MD.0000000000038322. https://pubmed.ncbi.nlm.nih.gov/39259123/
3. Bossuat, Margaux, Rullière, Pauline, Preuilh, Nadège, Britton, Sébastien, Génisson, Yves. 2023. Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids. In Journal of medicinal chemistry, 66, 13918-13945. doi:10.1021/acs.jmedchem.3c00859. https://pubmed.ncbi.nlm.nih.gov/37816126/
4. Cansby, Emmelie, Caputo, Mara, Andersson, Emma, Hoy, Andrew J, Mahlapuu, Margit. 2024. GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action. In Journal of lipid research, 65, 100669. doi:10.1016/j.jlr.2024.100669. https://pubmed.ncbi.nlm.nih.gov/39395791/
5. Bai, Rubing, Rebelo, Artur, Kleeff, Jörg, Sunami, Yoshiaki. 2021. Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis. In Lipids in health and disease, 20, 58. doi:10.1186/s12944-021-01476-y. https://pubmed.ncbi.nlm.nih.gov/34078402/
6. Duan, Xiaoran, Yang, Li, Wang, Liuya, Qin, Guohui, Zhang, Yi. 2022. m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer. In Cell & bioscience, 12, 60. doi:10.1186/s13578-022-00798-3. https://pubmed.ncbi.nlm.nih.gov/35568876/
7. Rotinen, Mirja, Villar, Joaquín, Celay, Jon, Notario, Vicente, Encío, Ignacio. 2011. Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells. In Molecular and cellular endocrinology, 339, 45-53. doi:10.1016/j.mce.2011.03.015. https://pubmed.ncbi.nlm.nih.gov/21549806/
8. Grant, Corena V, Cai, Shengxin, Risinger, April L, Cichewicz, Robert H, Mooberry, Susan L. 2020. CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells. In Journal of natural products, 83, 3080-3092. doi:10.1021/acs.jnatprod.0c00642. https://pubmed.ncbi.nlm.nih.gov/33021790/
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