Adss2-flox Mouse

Adss2, adenylosuccinate synthase 2, is one of the two isozymes of adenylosuccinate synthetase which catalyzes a key step in AMP synthesis. It is widely distributed in various tissues in pigs [1]. In cardiac myocytes, electrical stimulation represses the expression of Adss2, while activating the muscle-specific Adss1 isoform [4].

In pigs, a single nucleotide polymorphism (SNP, T/C(70)) in the ninth intron of Adss2 gene was significantly associated with average daily gain trait and loin muscle area trait [1]. In bladder cancer, SNP-SNP interactions located in ST7L-Adss2 were identified, some of which were positively or negatively associated with BC risk in different ethnic groups [2]. Also, alleles near Adss2 gene showed significant parent-of-origin effects in childhood asthma, with the maternally inherited G-allele at rs3003214 potentially contributing to the maternal effect in childhood asthma [3]. In tamoxifen-resistant invasive lobular carcinoma cells, the expression of Adss2 was increased, along with other nucleic acid biosynthesis enzymes [5].

In summary, Adss2 is involved in nucleotide biosynthesis and has associations with various traits and diseases such as growth-related traits in pigs, bladder cancer, childhood asthma, and tamoxifen-resistant invasive lobular carcinoma. These findings from different genetic association studies help to understand the role of Adss2 in specific biological processes and disease conditions.