Csrp1-flox Mouse
一般名
Csrp1-flox
製品ID
S-CKO-01922
背景情報
C57BL/6JCya
系統ID
CKOCMP-13007-Csrp1-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Csrp1-flox Mouse（カタログ番号S-CKO-01922）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Csrp1-flox
系統ID
CKOCMP-13007-Csrp1-B6J-VA
遺伝子名
製品ID
S-CKO-01922
遺伝子別名
CRP1, Csrp
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 1
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000097561
NCBIトランスクリプトID
NM_001360782
ターゲット領域
Exon 3~4
有効領域の大きさ
~2.7 kb
遺伝子研究の概要
Csrp1, also known as Cysteine and Glycine-Rich Protein 1, belongs to the cysteine-rich protein family and contains a unique double-zinc finger motif. It is important for development and cellular differentiation, and is a marker of smooth muscle lineages. Csrp1 interacts with Dishevelled 2 and Diversin, controlling cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways [5].
In colon cancer, lower Csrp1 expression is noted in tumors compared to normal colon tissue, yet patients with high Csrp1 expression have shorter recurrence-free, overall, and disease-specific survivals. Its expression is positively correlated with mesenchymal markers, EMT score, and stromal score, and is associated with CMS4 colon tumors. In colon adenocarcinoma, higher Csrp1 expression is correlated with worse prognosis and can promote tumor growth and migration [1,2].
In acute myeloid leukemia, Csrp1 shows notable expression variations between normal and tumor samples, is an independent prognostic factor, and correlates with immune-related pathways, immune cells, and immune checkpoints. Also, the METTL3/YTHDF1 axis stabilizes Csrp1 mRNA to regulate glycolysis and promote AML progression [3,4].
In hormone-sensitive prostate cancer, low Csrp1 expression promotes the advancement towards castration-resistant prostate cancer, making its expression level a potential biomarker [6].
In neuroblastoma, Csrp1 is involved in differentiation, apoptosis, and possibly innate immunity, and can enhance the effects of certain combination therapies [7].
In conclusion, Csrp1 is crucial for development and cellular differentiation, playing significant roles in multiple diseases such as colon cancer, acute myeloid leukemia, prostate cancer, and neuroblastoma. Functional studies, especially those related to its expression levels and associated pathways in these diseases, provide insights into its functions. Research on Csrp1 helps in understanding disease mechanisms and may offer new strategies for disease treatment.
References：
1. Demirkol Canli, Seçil. 2023. CSRP1 expression is associated with a mesenchymal, stroma-rich tumor profile and poor prognosis in colon cancer. In Turkish journal of medical sciences, 53, 1678-1689. doi:10.55730/1300-0144.5736. https://pubmed.ncbi.nlm.nih.gov/38813484/
2. Yu, Senlong, Zhao, Haifeng, Meng, Hongjie, Bian, Tianhua, Ruan, Canping. 2023. CSRP1 Promotes Colon Adenocarcinoma Growth and Serves as an Independent Risk Biomarker for Worse Prognosis. In Genetics research, 2023, 8586507. doi:10.1155/2023/8586507. https://pubmed.ncbi.nlm.nih.gov/37113556/
3. Zhao, Chunxia, Wang, Yulu, Wang, Huan, Schmidt-Wolf, Ingo G H, Wang, Zifeng. 2024. CSRP1 gene: a potential novel prognostic marker in acute myeloid leukemia with implications for immune response. In Discover oncology, 15, 248. doi:10.1007/s12672-024-01088-9. https://pubmed.ncbi.nlm.nih.gov/38937285/
4. Han, Lili, Wang, Ruiyan, He, Mengyu, Chen, Zhenyue, Wang, Feng. 2024. METTL3/YTDHF1 Stabilizes CSRP1 mRNA to Regulate Glycolysis and Promote Acute Myeloid Leukemia Progression. In Cell biochemistry and biophysics, , . doi:10.1007/s12013-024-01610-4. https://pubmed.ncbi.nlm.nih.gov/39565517/
5. Miyasaka, Kota Y, Kida, Yasuyuki S, Sato, Takayuki, Minami, Mari, Ogura, Toshihiko. 2007. Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin. In Proceedings of the National Academy of Sciences of the United States of America, 104, 11274-9. doi:. https://pubmed.ncbi.nlm.nih.gov/17592114/
6. Pan, Chenxi, Wang, Wei, He, Yi, Yang, Bo. 2025. Identification of CSRP1 as novel biomarker for hormone-sensitive prostate cancer by the combination of clinical and functional research. In Cancer cell international, 25, 65. doi:10.1186/s12935-025-03708-y. https://pubmed.ncbi.nlm.nih.gov/39994616/
7. Lin, Yu-Han, Jiang, Jyun-Hong, Chuang, Hui-Ching, Lian, Wei-Shiung, Chuang, Jiin-Haur. . The Involvement of CSRP1 in Neuroblastoma Differentiation and Apoptosis Impacting Tumor-Suppressive Therapeutic Responses. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 39, e70521. doi:10.1096/fj.202500403R. https://pubmed.ncbi.nlm.nih.gov/40198006/
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精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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