Caln1-flox Mouse
一般名
Caln1-flox
製品ID
S-CKO-02357
背景情報
C57BL/6JCya
系統ID
CKOCMP-140904-Caln1-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Caln1-flox Mouse（カタログ番号S-CKO-02357）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Caln1-flox
系統ID
CKOCMP-140904-Caln1-B6J-VA
遺伝子名
製品ID
S-CKO-02357
遺伝子別名
Cabp8, MNCb-0849, 9630012C17Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 5
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000111288
NCBIトランスクリプトID
NM_021371
ターゲット領域
Exon 4
有効領域の大きさ
~1.6 kb
遺伝子研究の概要
Caln1, also known as calneuron 1, is a member of the calmodulin superfamily. It encodes a neuron-specific protein mapping to chromosome 7q11, with potential roles in signal transduction due to its high homology with calmodulin. It may be significant in neuron physiology, potentially related to memory and learning [8]. It is also involved in membrane remodeling processes, interacting with proteins like APOL3 to control PI(4)P synthesis, which is crucial for infection-induced inflammation processes [4,7].
In bladder cancer, CALN1 hypomethylation is associated with advanced tumor stage, high histological grade, and is an independent risk factor for intravesical recurrence in non-muscle-invasive bladder cancer, suggesting its potential as a biomarker [1]. In schizophrenia, CALN1 has been identified as a target of miR-137, with miR-137 overexpression reducing CALN1 expression, indicating a possible role in the disease mechanism [2]. In glioma, CALN1 expression is decreased and positively correlated with prognosis, and its abnormal decrease may lead to the invasion of tumor-promoting immune cells, making it a potential prognostic marker and therapeutic target [3]. In aldosterone-producing adenoma, CALN1 overexpression increases Ca2+ in the endoplasmic reticulum and aldosterone production, and silencing CALN1 prevents aldosterone production, suggesting it as a potential therapeutic target for excess aldosterone production [5]. In metastatic osteosarcoma, exosomal miR-675 down-regulates CALN1 expression, promoting cell migration and invasion, and serum exosomal miR-675 may serve as a biomarker for metastasis [6].
In conclusion, Caln1 is involved in multiple biological processes and disease conditions. Its functions range from being potentially important in neuron-related physiological activities to playing roles in various cancers, schizophrenia, and aldosterone-related disorders. Studies on Caln1 contribute to understanding disease mechanisms and may offer new perspectives for biomarker discovery and therapeutic targeting.
References：
1. Takagi, Kimiaki, Naruse, Azumi, Akita, Kazutoshi, Horie, Masanobu, Kikuchi, Arizumi. 2022. CALN1 hypomethylation as a biomarker for high-risk bladder cancer. In BMC urology, 22, 176. doi:10.1186/s12894-022-01136-y. https://pubmed.ncbi.nlm.nih.gov/36352401/
2. Xia, Shihui, Zhou, Xinyao, Wang, Teng, He, Lin, Zhao, Xinzhi. 2015. Experimental validation of candidate schizophrenia gene CALN1 as a target for microRNA-137. In Neuroscience letters, 602, 110-4. doi:10.1016/j.neulet.2015.07.001. https://pubmed.ncbi.nlm.nih.gov/26163462/
3. Zhang, Han, Zhang, Jinhao, Wang, Tao. . [Bioinformatic analysis of the clinical significance of calneuron 1 (CALN1) in glioma and its correlation with immune cell infiltration]. In Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 39, 205-212. doi:. https://pubmed.ncbi.nlm.nih.gov/36946344/
4. Pays, Etienne. 2024. Apolipoprotein-L Functions in Membrane Remodeling. In Cells, 13, . doi:10.3390/cells13242115. https://pubmed.ncbi.nlm.nih.gov/39768205/
5. Kobuke, Kazuhiro, Oki, Kenji, Gomez-Sanchez, Celso E, Yoneda, Masayasu, Hattori, Noboru. 2017. Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma. In Hypertension (Dallas, Tex. : 1979), 71, 125-133. doi:10.1161/HYPERTENSIONAHA.117.10205. https://pubmed.ncbi.nlm.nih.gov/29109191/
6. Gong, Liangzhi, Bao, Qiyuan, Hu, Chuanzhen, Zhang, Weibin, Shen, Yuhui. 2018. Exosomal miR-675 from metastatic osteosarcoma promotes cell migration and invasion by targeting CALN1. In Biochemical and biophysical research communications, 500, 170-176. doi:10.1016/j.bbrc.2018.04.016. https://pubmed.ncbi.nlm.nih.gov/29626470/
7. Pays, Etienne. 2024. The Janus-faced functions of Apolipoproteins L in membrane dynamics. In Cellular and molecular life sciences : CMLS, 81, 134. doi:10.1007/s00018-024-05180-9. https://pubmed.ncbi.nlm.nih.gov/38478101/
8. Wu, Y Q, Lin, X, Liu, C M, Jamrich, M, Shaffer, L G. . Identification of a human brain-specific gene, calneuron 1, a new member of the calmodulin superfamily. In Molecular genetics and metabolism, 72, 343-50. doi:. https://pubmed.ncbi.nlm.nih.gov/11286509/
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凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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