Xrcc6-flox Mouse
一般名
Xrcc6-flox
製品ID
S-CKO-02517
背景情報
C57BL/6JCya
系統ID
CKOCMP-14375-Xrcc6-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Xrcc6-flox Mouse（カタログ番号S-CKO-02517）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Xrcc6-flox
系統ID
CKOCMP-14375-Xrcc6-B6J-VA
遺伝子名
製品ID
S-CKO-02517
遺伝子別名
Ku70, 70kDa, G22p1
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 15
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000069530
NCBIトランスクリプトID
NM_010247
ターゲット領域
Exon 4~5
有効領域の大きさ
~2.2 kb
遺伝子研究の概要
XRCC6, also known as Ku70, is a gene encoding a protein that plays a crucial role in the DNA non-homologous end-joining (NHEJ) pathway, which is the main mechanism for repairing DNA double-strand breaks (DSBs) in human cells. Maintaining genomic stability by repairing DSBs is essential in preventing tumor initiation and progression, thus XRCC6 is of great biological importance in carcinogenesis [2].
Multiple studies have investigated the association between XRCC6 polymorphisms and cancer risks. A meta-analysis showed that the rs2267437 polymorphism was associated with an increased risk of overall cancers, breast cancer, renal cell carcinoma, and hepatocellular carcinoma, especially in Asian populations [1]. Another study on nasopharyngeal carcinoma (NPC) found that the TC and CC genotypes of the XRCC6 promoter T-991C polymorphism were associated with a significantly increased NPC risk, and lower XRCC6 mRNA and protein expression was observed in NPC samples with these genotypes [3]. In a Taiwanese population, similar results were found for hepatocellular carcinoma (HCC), where the TC and CC genotypes of the XRCC6 promoter T-991C polymorphism increased the HCC risk, along with lower XRCC6 mRNA and protein expressions [4]. In esophageal squamous cell carcinoma (ESCC), the CG carriers and G allele carriers of rs2267437 were at a higher risk of ESCC [5]. In contrast, in the Polish population, the XRCC6 C1310G polymorphism was associated with a decreased risk of colorectal cancer [6]. Additionally, high expression of XRCC6 promoted human osteosarcoma cell proliferation through the β-catenin/Wnt signaling pathway [7].
In conclusion, XRCC6 is crucial for DNA double-strand break repair through the NHEJ pathway, which is significant in maintaining genomic stability and preventing carcinogenesis. Studies on XRCC6 polymorphisms have revealed its associations with various cancers, such as breast, renal cell, hepatocellular, nasopharyngeal, esophageal squamous cell, and colorectal cancers, as well as osteosarcoma, providing insights into the role of XRCC6 in different disease conditions.
References：
1. Jia, Jing, Ren, Juan, Yan, Dongmei, Xiao, Long, Sun, Ruifen. . Association between the XRCC6 polymorphisms and cancer risks: a systematic review and meta-analysis. In Medicine, 94, e283. doi:10.1097/MD.0000000000000283. https://pubmed.ncbi.nlm.nih.gov/25569644/
2. Bau, Da-Tian, Tsai, Chia-Wen, Wu, Cheng-Nan. . Role of the XRCC5/XRCC6 dimer in carcinogenesis and pharmacogenomics. In Pharmacogenomics, 12, 515-34. doi:10.2217/pgs.10.209. https://pubmed.ncbi.nlm.nih.gov/21521024/
3. Huang, C-Y, Tsai, C-W, Hsu, C-M, Shui, H-A, Bau, D-T. 2015. The role of XRCC6/Ku70 in nasopharyngeal carcinoma. In International journal of oral and maxillofacial surgery, 44, 1480-5. doi:10.1016/j.ijom.2015.06.008. https://pubmed.ncbi.nlm.nih.gov/26149939/
4. Hsu, Chin-Mu, Yang, Mei-Due, Chang, Wen-Shin, Tsai, Fuu-Jen, Bau, Da-Tian. . The contribution of XRCC6/Ku70 to hepatocellular carcinoma in Taiwan. In Anticancer research, 33, 529-35. doi:. https://pubmed.ncbi.nlm.nih.gov/23393345/
5. Li, Kun, Yin, Xiuli, Yang, Hongli, Xu, Changqing, Xu, Hongwei. 2015. Association of the genetic polymorphisms in XRCC6 and XRCC5 with the risk of ESCC in a high-incidence region of North China. In Tumori, 101, 24-9. doi:10.5301/tj.5000206. https://pubmed.ncbi.nlm.nih.gov/25702660/
6. Balinska, Kinga, Wilk, Damian, Filipek, Beata, Kabziński, Jacek, Majsterek, Ireneusz. . Association of XRCC6 C1310G and LIG4 T9I polymorphisms of NHEJ DNA repair pathway with risk of colorectal cancer in the Polish population. In Polski przeglad chirurgiczny, 91, 15-20. doi:10.5604/01.3001.0013.1030. https://pubmed.ncbi.nlm.nih.gov/31243170/
7. Zhu, Bin, Cheng, Dongdong, Li, Shijie, Zhou, Shumin, Yang, Qingcheng. 2016. High Expression of XRCC6 Promotes Human Osteosarcoma Cell Proliferation through the β-Catenin/Wnt Signaling Pathway and Is Associated with Poor Prognosis. In International journal of molecular sciences, 17, . doi:10.3390/ijms17071188. https://pubmed.ncbi.nlm.nih.gov/27455247/
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精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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